Comparative Analysis of RIRS Scoring System and Resorlu Unsal Stone Score (RUSS) for Predicting Stone-free Rate After Retrograde Intrarenal Surgery

NCT07026721 | Completed DMC

• 1 other identifier: 407(6-11)E2.080.081
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Several studies have investigated the use of scoring systems for predicting stone-free rates after RIRS. Previous research has evaluated the RIRS Scoring System, RUSS, and other similar systems in different patient populations. This study was conducted to compare RIRS scoring system and Resorlu Unsal Stone Score (RUSS) for predicting stone free rate.

Conditions

Renal Stones

Outcome Measures

Primary Outcomes (2)

• Correlation between the RIRS Scoring System and stone-free rate after Retrograde Intrarenal Surgery (RIRS), assessed using CT KUB

  12 months

• Correlation between the Resorlu-Unsal Stone Score (RUSS) and stone-free rate after Retrograde Intrarenal Surgery (RIRS), assessed using CT KUB

  12 months

Secondary Outcomes (2)

• Stone Burden as a Predictor of Stone-Free Rate After RIRS

  Preoperative assessment and 1 month postoperatively for stone-free status

• Stone Density as a Predictor of Stone-Free Rate After RIRS

  Preoperative assessment and 1 month postoperatively for stone-free status

Interventions

Retrograde intrarenal surgery (RIRS) PROCEDURE

The intervention involves Retrograde Intrarenal Surgery (RIRS) performed using a flexible ureteroscope to access the renal collecting system via a retrograde (urethra → bladder → ureter → kidney) approach. Stones are fragmented using a holmium:YAG laser, with or without the use of a ureteral access sheath, depending on the case. What distinguishes this intervention from others is the integration of preoperative scoring systems-specifically the RIRS Scoring System and the Resorlu Unsal Stone Score (RUSS)-to predict stone-free outcomes and guide case selection and surgical planning. Additionally, all procedures are performed by experienced endourologists following a standardized protocol, including consistent patient positioning, anesthesia, access technique, and post-operative imaging at defined intervals to assess outcomes.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All the patients with renal calculi undergoing RIRS.

You may qualify if:

• patients more than 18 years of age undergoing RIRS for renal stone
• providing informed written consent

You may not qualify if:

• Previous renal and ureteric surgeries
• coexisting bladder, ureteral stone

Sponsors & Collaborators

• Maharajgunj Medical Campus: lead

Study Sites (1)

Department of Urology and Kidney Transplant Surgery, Tribhuvan University Teaching Hospital (TUTH), Maharajgunj, Kathmandu, Nepal

Kathmandu, Bagmati, 44600, Nepal

Location

MeSH Terms

Conditions

Nephrolithiasis

Condition Hierarchy (Ancestors)

Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Urolithiasis; Male Urogenital Diseases

Study Officials

• Saro Prajapati, MBBS, MS

  Department of General Surgery Maharajgunj Medical Campus Institute of Medicine, Tribhuvan University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: June 3, 2025
• First Posted: June 18, 2025
• Study Start: January 1, 2024
• Primary Completion: December 27, 2024
• Study Completion: December 29, 2024
• Last Updated: June 18, 2025

Record last verified: 2024-01

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL

Locations

NE (1)