Effects of Peripheral Magnetic Stimulation on Cortical Excitability in Healthy Individuals
1 other identifier
interventional
18
1 country
1
Brief Summary
This study investigates the immediate effects of different parameters (frequency, intensity, and pulse number) of peripheral magnetic stimulation (rPMS) on cortical excitability in healthy individuals. Using a randomized, double-blind crossover design, the research aims to identify optimal stimulation protocols for modulating neural activity. Outcomes include measurements of motor-evoked potentials (MEPs), intracortical inhibition (ICI), and facilitation (ICF). Findings may enhance non-invasive therapeutic strategies for neurological disorders.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for phase_1
Started Oct 2022
Typical duration for phase_1
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2022
CompletedFirst Submitted
Initial submission to the registry
June 9, 2025
CompletedFirst Posted
Study publicly available on registry
June 17, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2025
CompletedJune 17, 2025
June 1, 2025
2.9 years
June 9, 2025
June 16, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Cortical excitabilty
Cortical excitability will be assessed through motor-evoked potentials (MEPs) elicited by single-pulse transcranial magnetic stimulation (TMS) over the primary motor cortex (M1), targeting the first dorsal interosseous (FDI) representation area. The hotspot will be determined as the site producing the largest MEP amplitude at the lowest intensity, with stimulation delivered at 100% of the resting motor threshold (RMT). Additionally, paired-pulse TMS protocols will evaluate intracortical inhibition (ICI) and facilitation (ICF) using conditioning stimuli at 80% RMT (3 ms interstimulus interval for ICI, 10 ms for ICF) and test stimuli at 120% RMT. MEP amplitudes will be recorded via surface electromyography (EMG) from the FDI muscle using bipolar electrode placement, with signals sampled at 20,000 Hz (bandpass 5-10,000 Hz) to capture corticospinal excitability changes across timepoints (baseline, post-intervention, and follow-ups).
Baseline (T0), immediately post-stimulation (T1), 15 minutes (T2), and 30 minutes (T3) post-stimulation.
Study Arms (9)
Peripheral magnetic stimulation (90% + 1 Hz)
ACTIVE COMPARATORPeripheral magnetic stimulation (100% + 25 Hz)
ACTIVE COMPARATORPeripheral magnetic stimulation (90% + 25 Hz)
ACTIVE COMPARATORPeripheral magnetic stimulation (100% + 1 Hz)
ACTIVE COMPARATORPeripheral magnetic stimulation (100% + 10 Hz)
ACTIVE COMPARATORPeripheral magnetic stimulation (110% + 1 Hz)
ACTIVE COMPARATORPeripheral magnetic stimulation (110% + 10 Hz)
ACTIVE COMPARATORPeripheral magnetic stimulation (110% + 25 Hz)
ACTIVE COMPARATORPeripheral magnetic stimulation (90% + 10 Hz)
ACTIVE COMPARATORInterventions
Low-frequency stimulation (1 Hz) at 90% of resting motor threshold intensity, delivering a total of 2400 pulses.
High-frequency stimulation (10 Hz) at 90% of resting motor threshold intensity, totaling 2400 pulses.
High-frequency stimulation (25 Hz) at 90% of resting muscle threshold intensity, with 2400 pulses.
Low-frequency (1 Hz), at resting motor threshold intensity (100%) protocol delivering 2400 pulses.
High-frequency (10 Hz), at resting motor threshold intensity (100%) protocol delivering 2400 pulses.
High-frequency (25 Hz), at resting motor threshold intensity (100%) protocol delivering 2400 pulses.
Low-frequency (1 Hz), above resting motor threshold intensity (110%) protocol delivering 2400 pulses.
High-frequency (10 Hz), above resting motor threshold intensity (110%) protocol delivering 2400 pulses.
High-frequency (25 Hz), above resting motor threshold intensity (110%) protocol delivering 2400 pulses.
Eligibility Criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Universidade Federal de Pernambuco
Recife, Pernambuco, Brazil
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- phase 1
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
June 9, 2025
First Posted
June 17, 2025
Study Start
October 1, 2022
Primary Completion
September 1, 2025
Study Completion
October 1, 2025
Last Updated
June 17, 2025
Record last verified: 2025-06
Data Sharing
- IPD Sharing
- Will not share