NLR and PLR Levels Following PENG Block in Hip Arthroplasty

NCT07023107 | Completed Phase 4

• 1 other identifier: 7/2025
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Effect of PENG block on NLR and PLR following hip arthroplasty

Conditions

Hip Arthropathy; Hip Osteoarthritis; Hip Pain Chronic

Outcome Measures

Primary Outcomes (1)

• Neutrophil-to-lymphocyte ratio

  Neutrophil to lymphocyte ratio (NLR) is used as a marker of subclinical inflammation. It is calculated by dividing the number of neutrophils by number of lymphocytes, usually from peripheral blood sample, but sometimes also from cells that infiltrate tissue, such as tumor.

  12 hours after surgery

Secondary Outcomes (11)

• PLR

  12 hours after surgery

• PLR

  24 hours after surgery

• PLR

  48 hours after surgery

• NLR

  24 hours after surgery

• NLR

  48 hours after surgery

Study Arms (2)

Sham blocks

PLACEBO COMPARATOR

PENG block with 20ml of 0.9% sodium chloride

Drug: 0.9% Sodium Chloride Injection

PENG block

ACTIVE COMPARATOR

PENG block with 20ml 0f 0.2% ropivacaine

Drug: Ropivacaine 0.2% Injectable Solution

Interventions

0.9% Sodium Chloride Injection DRUG

After spinal anesthesia, the ultrasound-guided PENG block will be performed with 20ml of 0.9% sodium chloride

Sham blocks

Ropivacaine 0.2% Injectable Solution DRUG

After spinal anesthesia, the ultrasound-guided PENG block will be performed with 20 ml of 0.2% ropivacaine

PENG block

Eligibility Criteria

• Age: 60 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with ASA classification I-III
• Aged 60-100 years
• Who will be scheduled for hip arthroplasty under spinal anesthesia

You may not qualify if:

• Patients who have a history of bleeding diathesis
• Take anticoagulant therapy
• History of chronic pain before surgery
• Multiple trauma
• patients unable to assess their pain (dementia)
• patients operated under general anesthesia
• patients having an infection in the region of the procedure
• the patient who does not accept the procedure

Sponsors & Collaborators

• Poznan University of Medical Sciences: lead

Study Sites (1)

Poznan University of Medical Sciences

Poznan, Poland

Location

MeSH Terms

Conditions

Osteoarthritis, Hip

Interventions

Sodium Chloride; Ropivacaine

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Intervention Hierarchy (Ancestors)

Chlorides; Hydrochloric Acid; Chlorine Compounds; Inorganic Chemicals; Sodium Compounds; Anilides; Amides; Organic Chemicals; Aniline Compounds; Amines

Study Officials

• Malgorzata Reysner, M.D. Ph.D.

  Poznan University of Medical Sciences

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 8, 2025
• First Posted: June 15, 2025
• Study Start: June 16, 2025
• Primary Completion: December 9, 2025
• Study Completion: December 9, 2025
• Last Updated: December 29, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will share

Locations

PL (1)