Assessment of Thyroid Dysfunction in Patients Undergoing Haemodialysis at Sohag University Hospital

NCT07022236 | Recruiting

• 1 other identifier: Soh-Med--25-4-012MS
• Study Type: observational
• Target: 1
• Locations: 1 country
• Sites: 1

Brief Summary

Thyroid dysfunction is a prevalent endocrine disorder that significantly impacts the health of patients with chronic kidney disease (CKD), particularly those undergoing dialysis. The prevalence of thyroid dysfunction in dialysis patients has been reported to range from 20% to 60%, highlighting the need for routine screening and management in this vulnerable group (Kuo et al., 2024). Thyroid hormones play a crucial role in regulating various physiological processes, and their dysregulation can lead to complications such as cardiovascular disease, anemia, and impaired quality of life, which are particularly concerning in the dialysis population (Smith et al., 2024). The relationship between CKD and thyroid dysfunction is complex and multifactorial. Uremic toxins can interfere with the hypothalamic-pituitary-thyroid axis, leading to alterations in thyroid hormone production and metabolism. Recent studies have shown that inflammation and oxidative stress associated with CKD can further exacerbate thyroid dysfunction (Johnson et al., 2024). Understanding these mechanisms is essential for developing effective management strategies for thyroid health in dialysis patients.

Conditions

Dialysis; Complications

Outcome Measures

Primary Outcomes (1)

• Number of Participants With Thyroid Dysfunction Diagnosed by Serum TSH, Free T3, and Free T4 Levels

  Diagnosis will be classified as: Hypothyroidism Subclinical hypothyroidism Hyperthyroidism

  Up to 6 months from enrollment

Secondary Outcomes (1)

• Number of Participants With Thyroid Dysfunction Stratified by Dialysis Duration and Ultrafiltration Rate

  Up to 6 months from enrollment

Other Outcomes (1)

• Number of Participants With Thyroid Dysfunction by Underlying Cause of Kidney Disease

  Up to 6 months from enrollment

Interventions

Thyroid profile DIAGNOSTIC_TEST

Thyroid dysfunction in patients undergoing hemogdialysis in sohag university hospital

Eligibility Criteria

• Age: 13 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients undergoing hemodialysis in sohag university hospital

You may qualify if:

• Adults aged 18 years and older.
• Patients diagnosed with end-stage renal disease (ESRD) on regular hemodialysis for at least 3 months.

You may not qualify if:

• Known Thyroid Disorders: Patients with a history of thyroid disease (e.g., hypothyroidism, hyperthyroidism) prior to starting dialysis.
• Recent Thyroid Treatment: Patients who have received treatment for thyroid dysfunction (e.g., thyroid hormone replacement, antithyroid medications) within the last six months.
• Patients with acute kidney injury (AKI) or those who are not on regular dialysis.
• Pregnant or lactating women.
• Patients with systemic illnesses or medications that could interfere with thyroid function tests (e.g., corticosteroids, lithium).

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Hospital

Sohag, Egypt

RECRUITING

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Internal Medicine Resident

Study Record Dates

• First Submitted: May 24, 2025
• First Posted: June 15, 2025
• Study Start: April 13, 2025
• Primary Completion: October 13, 2025
• Study Completion: October 30, 2025
• Last Updated: June 15, 2025

Record last verified: 2025-06

Locations

EG (1)