NCT07019428

Brief Summary

The aim of this randomized, controlled, parallel-grouped, clinical trial is to evaluate the width of keratinized gingiva after free gingival graft stabilized by titanium fixation tacs compared to traditional suturing. Research question: In patients with inadequate keratinized gingiva undergoing soft tissue augmentation by free gingival graft , will graft stabilization using Titanium fixation tacs affect the amount of keratinized tissue gain compared to graft stabilization using sutures ?

Trial Health

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Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
26

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Nov 2024

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 2, 2024

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

January 2, 2025

Completed
5 months until next milestone

First Posted

Study publicly available on registry

June 13, 2025

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2025

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2026

Completed
Last Updated

June 13, 2025

Status Verified

May 1, 2025

Enrollment Period

1.1 years

First QC Date

January 2, 2025

Last Update Submit

June 12, 2025

Conditions

Keywords

Free gingival graftTitanium tacksKeratinized tissue

Outcome Measures

Primary Outcomes (1)

  • Width of keratinized gingiva

    6-month

Secondary Outcomes (1)

  • Surgery time

    Perioperative

Study Arms (2)

Free gingival graft stabilized by sutures

ACTIVE COMPARATOR
Procedure: Free gingival graft stabilized by sutures

Free gingival graft stabilized by by Titanium fixation tacs

EXPERIMENTAL
Procedure: Free gingival graft stabilized by Titanium fixation tacs

Interventions

Free gingival graft stabilized by Titanium fixation tacs , in patients with inadequate keratinized gingiva

Free gingival graft stabilized by by Titanium fixation tacs

Free gingival graft stabilized by sutures , in patients with inadequate keratinized gingiva

Free gingival graft stabilized by sutures

Eligibility Criteria

Age18 Years - 40 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Systemically healthy individuals of age ≥ 18 to 40 years with absence of active periodontal disease.
  • Having inadequate width of keratinized gingiva (\< 2 mm).
  • No systemic disease according to Modified Cornell Medical Index health questionnaire
  • Non-smoker.
  • Full mouth plaque index (PI) and full-mouth bleeding on probing (BOP) score of ≤ 15%.
  • No malocclusion, crowding, fillings, missing or supernumerary mandibular anterior teeth.
  • No blood-borne conditions.

You may not qualify if:

  • Active orthodontic treatment.
  • Previous periodontal surgery.
  • Systemic disease.
  • Use of blood thinners.
  • Use of any drugs that might lead to gingival enlargement.
  • Mucogingival stress, bruxism.
  • Pregnancy or lactation.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Faculty of Dentistry, Cairo University

Cairo, 11511, Egypt

RECRUITING

Study Officials

  • Amr Zahran, Professor of Periodontology

    Cairo University

    PRINCIPAL INVESTIGATOR
  • Manar El Zanaty, lecturer of Periodontology

    Cairo University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Mohamed Atef Kamal Ibrahim, Bds

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

January 2, 2025

First Posted

June 13, 2025

Study Start

November 2, 2024

Primary Completion

December 1, 2025

Study Completion

February 1, 2026

Last Updated

June 13, 2025

Record last verified: 2025-05

Locations