We Analyse Metabolites in Dried Blood Spots From Newborns That Later in Life Developed an Eating Disorder.

NCT07016334 | Active Not Recruiting

• 1 other identifier: Analysis of blood spots in ED
• Study Type: observational
• Target: 3,000
• Locations: 1 country
• Sites: 1

Brief Summary

Anorexia nervosa (AN) and bulimia nervosa (BN) are serious eating disorders (EDs) with significant morbidity and mortality. Genetic studies have shown associations between EDs and metabolic traits, and longitudinal studies indicate distinct weight trajectories in children who later develop AN or BN, suggesting early involvement of metabolic factors. Biological studies also reveal differences in immune and neurotrophic markers in individuals with EDs compared to controls. Intriguingly, metabolites measured in neonatal blood could serve as very early markers of ED risk, unconfounded by state or scar factors related to prolonged starvation. Here the investigators propose to comprehensively analyze neonatal biomarkers (metabolic, immune, and neurotrophic), epidemiological factors, and genetics to understand ED risk and develop risk prediction models

Conditions

Eating Disorders

Outcome Measures

Primary Outcomes (1)

• Metabolomic factors measured by mass-spectrometry

  Metabolomic factors such as amino acids, sugars, lipids, and organic acids extracted from dried blood spots sampled at birth are measured by mass spectrometry

  Sampled at birth (day 1)

Study Arms (3)

Anorexia nervosa

Diagnosed (life-time) with anorexia nervosa

Bulimia nervosa

Diagnosed (life-time) with bulimia nervosa

Controls

Never diagnosed with anorexia or bulimia nervosa

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Population born from 1981 with/or with out diagnosis of anorexia or bulimia nervosa

You may qualify if:

• \- in PKU-register with or withou life-time diagnosis of anorexia or bulimi nervosa

You may not qualify if:

• not in PKU register

Sponsors & Collaborators

• Karolinska Institutet: lead

Study Sites (1)

Karolinska Institutet

Stockholm, 17176, Sweden

Location

MeSH Terms

Conditions

Feeding and Eating Disorders

Condition Hierarchy (Ancestors)

Signs and Symptoms, Digestive; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Mental Disorders

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 44 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: May 21, 2025
• First Posted: June 11, 2025
• Study Start: September 1, 2022
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2027
• Last Updated: June 11, 2025

Record last verified: 2025-05

Locations

SE (1)