Pleural Effusion Biomarkers in Lung Adenocarcinoma Patients

NCT07012759 | Recruiting

• 1 other identifier: FJUH113386
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This project aims to assess the expression levels of novel molecular markers identified through screening in clinical samples of malignant pleural effusion, to evaluate the feasibility and clinical utility of these markers as potential diagnostic genes for lung adenocarcinoma.

Conditions

Biomarkers; Lung Adenocarcinoma; Pleural Effusion

Keywords

Pleural effusion; biomarkers; lung cancer; clinical diagnosis

Outcome Measures

Primary Outcomes (1)

• target gene expression levels between malignant and non-malignant pleural effusions

  Novel biomarkers specifically expressed in malignant pleural effusions may provide additional diagnostic options for malignant lung cancer in clinical diagnosis

  20 minutes

Study Arms (2)

Case group

Patients with pleural effusion diagnosed as lung adenocarcinoma.

Other: biomarkers

Control group

Patients with pleural effusion diagnosed as non-malignant.

Other: biomarkers

Interventions

biomarkers OTHER

pleural effusion biomarkers in lung adenocarcinoma

Case group; Control group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The control group consists of non-malignant pleural effusion, while the case group includes those diagnosed with pleural effusion with lung adenocarcinoma.

You may qualify if:

• Patients requiring thoracentesis for pleural effusion drainage as determined by a physician based on clinical need.
• Signed informed consent.

You may not qualify if:

• Patients under the age of 18.
• Patients with malignancies other than lung adenocarcinoma.

Sponsors & Collaborators

• Fu Jen Catholic University: lead

Study Sites (1)

Fu Jen Catholic University Hospital, Fu Jen Catholic University

New Taipei City, 24352, Taiwan

RECRUITING

MeSH Terms

Conditions

Adenocarcinoma of Lung; Pleural Effusion; Lung Neoplasms

Interventions

Biomarkers

Condition Hierarchy (Ancestors)

Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Pleural Diseases; Respiratory Tract Diseases; Lung Diseases

Intervention Hierarchy (Ancestors)

Biological Factors

Study Officials

• Ke-Yun Chao, PhD

  Fu Jen Catholic University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ke-Yun Chao, PhD

CONTACT

+886905301879; ck_qq@hotmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: June 1, 2025
• First Posted: June 10, 2025
• Study Start: June 10, 2025
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: March 5, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)