Risk Factors and Multiomics Study of Chronic Kidney Disease Caused by Metabolic Diseases

NCT05476627 | Recruiting

• 1 other identifier: JS-2136
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

With the development of China's economy, people's living standard have improved, and the dietary structure have changed. Metabolic diseases, such as hypertension, diabetes, hyperuricemia and obesity have gradually become an important health burden in China. The pathophysiological mechanism of renal injury caused by metabolic diseases has always been a hotspot of research. Currently, it is believed that various mechanisms including the activation of Renin-Angiotensin-Aldosterone System, vascular endothelial dysfunction, oxidative stress and inflammatory process may be involved. Although there are differences in renal pathological manifestations caused by different metabolic diseases, the kidney will eventually present ischemic changes and fibrosis with the progression of the disease. So there must be some common pathogenesis. This study is designed to build a disease cohort of patients with chronic kidney disease caused by metabolic diseases, to identify risk factors leading to disease progression and to explore biomarkers for early diagnosis and treatment of kidney damage.

Conditions

Chronic Kidney Diseases; Hypertension; Diabetes Mellitus; Hyperuricemia; Obesity

Keywords

chronic kidney disease; metabolic diseases; biomarker; functional imaging techniques

Outcome Measures

Primary Outcomes (3)

• Number of Participants with End Stage Renal Disease

  End Stage Renal Disease

  3 years

• Number of Participants with Adverse cardiovascular events

  Adverse cardiovascular events

  3 years

• Number of Participants with all cause death

  All cause death

  3 years

Secondary Outcomes (4)

• Number of Participants with eGFR decline

  3 years

• Number of Participants with Complications of CKD

  3 years

• Life quality assessment with short form-36 (SF-36)

  3 years

• Advanced Intelligence Assessment with Mini-Mental State Examination (MMSE)

  3 years

Study Arms (4)

Hypertension Group

Diagnostic Test: Biomarkers

Diabetes Group

Diagnostic Test: Biomarkers

Hyperuricemia

Diagnostic Test: Biomarkers

Obesity

Diagnostic Test: Biomarkers

Interventions

Biomarkers DIAGNOSTIC_TEST

Blood,urine and imaging biomarkers for early diagnosis and prediction of prognosis.

Diabetes Group; Hypertension Group; Hyperuricemia; Obesity

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population is consecutively enrolled from outpatient and inpatient department of our hospital.

You may qualify if:

• The diagnosis of metabolic diseases were confirmed;
• Be able to understand the process of the research;
• Volunteer for participation and be able to sign the informed consent.

You may not qualify if:

• Age \<18 yrs or \>80yrs;
• Patients with primary and secondary glomerular diseases
• Patients with other comorbidities that could affect the volume or the components of the kidney, such as renal cysts, polycystic kidney disease, medullary sponge kidney, hydronephrosis, renal artery stenosis, renal vein thrombosis and/or renal tumors;
• Contraindications for MRI examination;
• Pregnant or lactation patients;
• Patients with unstable vital signs, failure of other organs or dysphoria.

Sponsors & Collaborators

• Peking Union Medical College Hospital: lead

Study Sites (1)

Peking Union Medical College Hospital

Beijing, Beijing Municipality, 100730, China

RECRUITING

MeSH Terms

Conditions

Renal Insufficiency, Chronic; Hypertension; Diabetes Mellitus; Hyperuricemia; Obesity; Metabolic Diseases

Interventions

Environmental Biomarkers

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Vascular Diseases; Cardiovascular Diseases; Glucose Metabolism Disorders; Nutritional and Metabolic Diseases; Endocrine System Diseases; Overweight; Overnutrition; Nutrition Disorders; Body Weight; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Biomarkers; Biological Factors; Biological Phenomena; Environmental Monitoring; Environmental Exposure; Environmental Pollution; Public Health; Environment and Public Health

Study Officials

• Limeng Chen

  Peking Union Medical College Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Yan Liu

CONTACT

+86-15811568692; liuyanpumch@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: director of the department of nephrology

Study Record Dates

• First Submitted: July 25, 2022
• First Posted: July 27, 2022
• Study Start: July 1, 2022
• Primary Completion: July 1, 2025
• Study Completion (Estimated): July 1, 2027
• Last Updated: August 16, 2022

Record last verified: 2022-08

Locations

CN (1)