Color Doppler Ultrasonography Evaluation of Abdominal and Peripheral Vasculopathy in Systemic Sclerosis Patients

NCT07012655 | Completed DMC

• 1 other identifier: SFA12025
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

In the current study we aim to assess the macrovascular involvement in SSc patients through an ultrasound (US) evaluation of radial and ulnar arteries and splanchnic vessels.

Conditions

Systemic Sclerosis

Keywords

systemic sclerosis; Doppler Ultrasound

Outcome Measures

Primary Outcomes (1)

• Macro vascular involvement in systemic sclerosis patients

  Assess the macro vascular involvement in SSc patients through an ultrasound (US) evaluation of radial and ulnar arteries and splanchnic vessels.

  day 1

Interventions

Colour Doppler Ultrasound DEVICE

All study participants will undergo abdominal Ultrasound and Colour doppler ultrasound study of the superior and inferior mesenteric arteries and the resistance index and peak systolic velocity (cm/s) of radial and ulnar arteries measured by ultrasonography color Doppler with spectral wave analysis.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study will include 50 participants: Group 1: 25 Adult Systemic sclerosis fulfilling the criteria for the diagnosis by American College of Rheumatology /European league against rheumatism 2013 classification criteria for systemic sclerosis. Group 2: 25 healthy matched controls.

You may qualify if:

• Adult systemic sclerosis patients fulfilling the criteria for the diagnosis by American College of Rheumatology /European league against rheumatism 2013 classification criteria for systemic sclerosis, who accept to participate in the current study.

You may not qualify if:

• Individuals with other autoimmune diseases (rheumatoid arthritis, dermatomyositis, mixed connective tissue disease).
• those who Refuse to participate in the current study.

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Assiut University hospital

Asyut, 71515, Egypt

Location

Related Publications (2)

• Lescoat A, Coiffier G, Rouil A, Droitcourt C, Cazalets C, de Carlan M, Perdriger A, Jego P. Vascular Evaluation of the Hand by Power Doppler Ultrasonography and New Predictive Markers of Ischemic Digital Ulcers in Systemic Sclerosis: Results of a Prospective Pilot Study. Arthritis Care Res (Hoboken). 2017 Apr;69(4):543-551. doi: 10.1002/acr.22965. Epub 2017 Mar 3.

  PMID: 27390194 BACKGROUND

• Romano E, Rosa I, Fioretto BS, Matucci-Cerinic M, Manetti M. Increased Circulating Soluble Junctional Adhesion Molecules in Systemic Sclerosis: Association with Peripheral Microvascular Impairment. Life (Basel). 2022 Nov 4;12(11):1790. doi: 10.3390/life12111790.

  PMID: 36362943 BACKGROUND

MeSH Terms

Conditions

Scleroderma, Systemic

Condition Hierarchy (Ancestors)

Connective Tissue Diseases; Skin and Connective Tissue Diseases; Skin Diseases

Study Officials

• Sara Farrag, Lecturer

  Assiut University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Rheumatology and Rehabilitation

Study Record Dates

• First Submitted: June 1, 2025
• First Posted: June 10, 2025
• Study Start: May 1, 2024
• Primary Completion: March 1, 2025
• Study Completion: March 30, 2025
• Last Updated: June 10, 2026

Record last verified: 2026-06

Locations

EG (1)