Respiratory Functions in Parkinson's Disease

NCT07010783 | Recruiting

• 1 other identifier: E-59394181-604.01-112206
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The aim is to examine respiratory functions, inspiratory muscle strength, respiratory function, physical fitness and aerobic capacity in Parkinson's disease patients. Individuals between the ages of 50-80 who have been diagnosed with Parkinson's disease by a neurologist and healthy individuals with similar demographic characteristics will be included in the study as a control group. In addition, patients will be divided into three groups as above and below 2.5 and healthy controls according to the Modified Hoehn and Yahr Scale. Demographic information of the individuals will be recorded and clinical evaluations will be made. The staging of Parkinson's patients will be done with the Modified Hoehn and Yahr Scale, and the severity of the disease will be done with the Unified Parkinson's Disease Rating Scale. The inspiratory muscle strength of the individuals will be evaluated with the PowerBreath K5, respiratory functions with the Pulmonary Function Test device, and physical fitness and aerobic capacity with the Senior Fitness Test.

Conditions

Parkinson Disease

Outcome Measures

Primary Outcomes (4)

• Inspiratory Muscle Strength Measurement

  In this study, the inspiratory muscle strength of the participants will be measured using the Power Breath device.

  Baseline

• Unified Parkinson's Disease Rating Scale

  This scale will evaluate the severity and stage of the participants' Parkinson's disease.

  Baseline

• Evaluation of Respiratory Functions

  Participants' respiratory functions will be evaluated using a standard respiratory function test device.

  Baseline

• Senior Fitness Test

  The physical fitness levels of the participants will be evaluated using the Senior Fitness Test.

  Baseline

Study Arms (3)

Early Stage Patients with Parkinson's Disease

According to the Modified Hoehn and Yahr Scale (MHÖ), patients with a score below 2.5

Advanced Stage Patients with Parkinson's Disease

According to the Modified Hoehn and Yahr Scale (MHÖ), patients with 2.5 and above

Control Group

Healthy individuals with similar demographic characteristics

Eligibility Criteria

• Age: 50 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with Parkinson's disease who came to the neurology outpatient clinic for routine examination and who met the appropriate inclusion criteria and healthy individuals with similar demographic characteristics.

You may qualify if:

• Age 50 to 80
• Mini Mental State Examination score of 24 to 30
• Diagnosed with Parkinson's Disease by a neurologist

You may not qualify if:

• Sözlü iletişim kuramama
• Yürüme yardımcısı kullanıma
• Ciddi görme bozukluğu, ek nörolojik bozuklukları ve/veya konjestif kalp yetmezliği olan yaşlılar
• Egzersiz yapılması tavsiye edilmeyen yaşlı yetişkinler.

Sponsors & Collaborators

• Ankara University: lead
• Hacettepe University: collaborator
• Atılım University: collaborator

Study Sites (1)

Atılım University

Ankara, Turkey (Türkiye)

RECRUITING

Related Publications (2)

• Shill H, Stacy M. Respiratory function in Parkinson's disease. Clin Neurosci. 1998;5(2):131-5.

  PMID: 10785839 RESULT

• Morris ME, Iansek R, Matyas TA, Summers JJ. Ability to modulate walking cadence remains intact in Parkinson's disease. J Neurol Neurosurg Psychiatry. 1994 Dec;57(12):1532-4. doi: 10.1136/jnnp.57.12.1532.

  PMID: 7798986 RESULT

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Officials

• Süleyman Korkusuz, PhD

  Atılım University

  STUDY CHAIR

• Ayla Fil Balkan, Assoc Prof

  Hacettepe University

  STUDY CHAIR

• Gül Yalçın Çakmaklı, Assoc Prof

  Hacettepe University

  STUDY CHAIR

• Neslihan Durutürk, Prof.Dr

  Baskent University

  STUDY CHAIR

Central Study Contacts

Büşra Seçkinoğulları Korkusuz, PhD

CONTACT

+905442436914; bskorkusuz@ankara.edu.tr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: May 30, 2025
• First Posted: June 8, 2025
• Study Start: July 1, 2025
• Primary Completion: April 1, 2026
• Study Completion: May 1, 2026
• Last Updated: March 24, 2026

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)