NCT06995131|CompletedResultsDMC
Evaluation of Aqueous Humor DEL-1 and IL-17 Levels in Diabetic Cataract Patients
DEL-1 and IL-1
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Sponsor study identifier
observational
61
1 country
1
Study Start
May 1, 2025
Actual (reported)Primary Completion
October 1, 2025
Actual (reported)Study Completion
October 15, 2025
Actual (reported)By comparing DEL-1 and IL-17 levels in the aqueous humor of diabetic cataract patients with the aqueous humor of non-diabetic patients, we aim to understand the biochemical effects of diabetes-related inflammatory processes in the eye.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
October 15, 2025
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 1, 2025
Actual (reported)May 20, 2025
Actual (reported)May 29, 2025
Actual (reported)October 1, 2025
Actual (reported)October 15, 2025
Actual (reported)October 19, 2026
Actual (reported)DEL-1 and IL-17 Levels
Aqueous humor DEL-1 and IL-17 concentrations were measured quantitatively using ELISA and are reported in pg/mL.
During cataract surgery, at the time of aqueous humor collection
HbA1c
Preoperative, before cataract surgery
Association Between Aqueous Humor DEL-1 and IL-17 Levels
During cataract surgery, at the time of aqueous humor collection
Association of Biomarker Levels With HbA1c
Perioperative, based on the most recent HbA1c measurement available before cataract surgery
Association Between Demographic Variables and DEL-1/IL-17 Levels
During cataract surgery, at the time of aqueous humor collection
Patients with type 2 diabetes and cataract without diabetic retinopathy.
Non-diabetic patients undergoing cataract surgery.
No intervention was administered. This was a prospective observational case-control study. Participants underwent routine ophthalmologic examinations and aqueous humor sampling during cataract surgery.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
* Patients scheduled for cataract surgery * Diabetic cataract patients (diagnosed with Type 2 Diabetes and HbA1c measured) * Nondiabetic cataract patients (without a diagnosis of diabetes)
Usak University Training and Research Hospital
Uşak, 64200, Turkey (Türkiye)
Dogruya S, Sagkan RI. Levels of DEL-1 and IL-17 in the aqueous humor of cataract patients with diabetes without diabetic retinopathy. Int Ophthalmol. 2026 Jun 25;46(1):270. doi: 10.1007/s10792-026-04142-3.
This study had a relatively small sample size and was limited to patients undergoing cataract surgery at a single center, which may affect the generalizability of the findings. Additionally, the cross-sectional design precludes assessment of causality or long-term dynamics of DEL-1 and IL-17 levels. The absence of patients with diabetic retinopathy limits the ability to evaluate the role of these markers in advanced ocular inflammation.
61 participants (actual enrollment reported by the registry).
First Submitted
May 20, 2025
First Posted
May 29, 2025
Study Start
May 1, 2025
Actual (reported)Contact the study team to confirm eligibility.
Primary Completion
October 1, 2025
Actual (reported)Study Completion
October 15, 2025
Actual (reported)Last Updated
October 19, 2026
Results First Posted
October 19, 2026
Record last verified: 2026-07
Individual participant data (IPD) obtained in this study will be shared anonymised with requesting researchers for reasonable research purposes and in accordance with ethical rules.
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Source: ClinicalTrials.gov.
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