Analysis of the Interaction Between Preoperative Lifestyle and Clinical Characteristics of Cardiac Surgery Patients and Perioperative Complications

NCT06991218 | Completed DMC

• 2 other identifiers: NFEC-2023-5872023YFC2506900
• Study Type: observational
• Target: 1,366
• Locations: 1 country
• Sites: 1

Brief Summary

Each year, over four million patients die within 30 days after surgery, accounting for 7.7% of global deaths. Due to its unique nature, cardiac surgery carries a significantly higher risk of perioperative complications and long-term mortality compared to non-cardiac surgeries. Therefore, the identification, management, and prevention of perioperative complications in cardiac surgery have long been a clinical focus. Common manifestations of perioperative organ injury include neurological complications, acute kidney injury, respiratory failure, gastrointestinal dysfunction, and liver injury. This study aims to explore the association between preoperative lifestyle and postoperative complications in cardiac surgery, as well as their interaction with clinical characteristics, in order to facilitate the prediction and prevention of perioperative complications. This retrospective cohort study plans to include adult patients undergoing elective cardiac surgery as the object of study. Different preoperative lifestyle habits will be considered as exposure factors to investigate the relationships between these exposure factors and the occurrence of major organ complications after cardiac surgery.

Conditions

Acute Kidney Injury; Cardiac Surgery; Hemoglobin; Perioperative Complications

Keywords

acute kidney injury; cardiac surgery; hemoglobin trajectory; Perioperative complications

Outcome Measures

Primary Outcomes (1)

• The occurrence of perioperative complications of important organs

  The occurrence of perioperative complications of important organs (including the nervous system, respiratory system, urinary system, etc.)

  Within 30 days after the operation.

Secondary Outcomes (3)

• Acute kidney injury (AKI)

  Within 7 days postoperatively.

• Acute respiratory distress syndrome

  Within 30 days after the operation.

• Perioperative stroke

  Within 30 days after the operation.

Study Arms (1)

Study Group

The subjects of this study were patients aged 18 and above who underwent elective cardiac surgery.

Procedure: cardiac surgery

Interventions

cardiac surgery PROCEDURE

Adult patients (age ≥18 years) who underwent cardiac surgery with cardiopulmonary bypass were included.

Study Group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients (age ≥18 years) who underwent cardiac surgery with cardiopulmonary bypass in a large-scale comprehensive hospital between January 1, 2019 and October 31, 2023, were included.

You may qualify if:

• Age ≥ 18 years old.
• Patients scheduled for elective cardiac surgery.
• Patients who received medical care at hospital from January 2018 to November 2022.

You may not qualify if:

• Pregnant women.
• Patients whose preoperative examinations indicated they had already met the diagnostic criteria for acute kidney injury (AKI) or acute respiratory distress syndrome (ARDS).
• Patients with severe preoperative abnormalities in liver or kidney function.
• Patients with more than 10% missing data in their basic clinical information.
• Patients with mental disorders.

Sponsors & Collaborators

• Nanfang Hospital, Southern Medical University: lead

Study Sites (1)

Nanfang Hospital, Southern Medical University

Guangzhou, Guangdong, 510515, China

Location

Related Publications (4)

• Glance LG, Lustik SJ, Hannan EL, Osler TM, Mukamel DB, Qian F, Dick AW. The Surgical Mortality Probability Model: derivation and validation of a simple risk prediction rule for noncardiac surgery. Ann Surg. 2012 Apr;255(4):696-702. doi: 10.1097/SLA.0b013e31824b45af.

  PMID: 22418007 BACKGROUND

• Oprea AD, Del Rio JM, Cooter M, Green CL, Karhausen JA, Nailer P, Guinn NR, Podgoreanu MV, Stafford-Smith M, Schroder JN, Fontes ML, Kertai MD. Pre- and postoperative anemia, acute kidney injury, and mortality after coronary artery bypass grafting surgery: a retrospective observational study. Can J Anaesth. 2018 Jan;65(1):46-59. doi: 10.1007/s12630-017-0991-0. Epub 2017 Nov 2.

  PMID: 29098634 BACKGROUND

• Section 2: AKI Definition. Kidney Int Suppl (2011). 2012 Mar;2(1):19-36. doi: 10.1038/kisup.2011.32. No abstract available.

  PMID: 25018918 BACKGROUND

• Cao L, Ru W, Hu C, Shen Y. Interaction of hemoglobin, transfusion, and acute kidney injury in patients undergoing cardiopulmonary bypass: a group-based trajectory analysis. Ren Fail. 2022 Dec;44(1):1368-1375. doi: 10.1080/0886022X.2022.2108840.

  PMID: 35946481 BACKGROUND

Related Links

• Definition and classification of AKI.

MeSH Terms

Conditions

Acute Kidney Injury

Interventions

Cardiac Surgical Procedures

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Intervention Hierarchy (Ancestors)

Cardiovascular Surgical Procedures; Surgical Procedures, Operative; Thoracic Surgical Procedures

Study Officials

• Ke-Xuan Liu, Doctor

  Department of Anesthesiology, Nanfang Hospital, Southern Medical University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 19, 2025
• First Posted: May 27, 2025
• Study Start: December 1, 2023
• Primary Completion: June 1, 2024
• Study Completion: December 1, 2024
• Last Updated: May 27, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)