Neutral Endopeptidase for Early Detection of Acute Kidney Injury After Cardiac Surgery
NEPAKI-CS
1 other identifier
observational
100
1 country
1
Brief Summary
The investigators want to investigate if the urinary biomarker neprilysin can identify cardiac surgical patients suffering from postoperative AKI within 24 hours.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Oct 2016
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 30, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 25, 2018
CompletedFirst Submitted
Initial submission to the registry
February 24, 2019
CompletedFirst Posted
Study publicly available on registry
February 26, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2019
CompletedApril 22, 2019
April 1, 2019
1.2 years
February 24, 2019
April 19, 2019
Conditions
Outcome Measures
Primary Outcomes (1)
NEP-levels
Difference of NEP-levels after cardiac surgery on the first postoperative day
24 hours
Secondary Outcomes (2)
NEP-levels
approximately 6 hours
Increase of NEP
approximately 6 hours
Study Arms (2)
AKI
patients with postoperative AKI defined by KDIGO
no AKI
patients without postoperative AKI defined by KDIGO
Interventions
Eligibility Criteria
Elective cardiac surgical patients
You may qualify if:
- \- Patients undergoing an elective cardiac surgical intervention
You may not qualify if:
- Emergency procedures
- Heart transplantation
- Elective left ventricular assist device (LVAD) implantation
- Pulmonary thrombendarterectomy
- Declined informed consent
- Age \< 18 years
- Pregnant woman
- Preoperative renal replacement therapy (RRT)
- Receiving medication containing sacubitril
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Divison of Cardiothoracic Anaesthesia and Intensive Care, Medical University of Vienna
Vienna, 1090, Austria
Related Publications (1)
Bernardi MH, Wagner L, Ryz S, Puchinger J, Nixdorf L, Edlinger-Stanger M, Geilen J, Kainz M, Hiesmayr MJ, Lassnigg A. Urinary neprilysin for early detection of acute kidney injury after cardiac surgery: A prospective observational study. Eur J Anaesthesiol. 2021 Jan;38(1):13-21. doi: 10.1097/EJA.0000000000001321.
PMID: 32941200DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Neutral Endopeptidase for early detection of acute kidney injury after cardiac surgery
Study Record Dates
First Submitted
February 24, 2019
First Posted
February 26, 2019
Study Start
October 30, 2016
Primary Completion
January 25, 2018
Study Completion
April 1, 2019
Last Updated
April 22, 2019
Record last verified: 2019-04