Clinical Evaluation of Two Different Surgical Techniques With PRF in the Treatment of Multiple Gingival Recessions

NCT06986525 | Not Yet Recruiting

• 1 other identifier: E-60116787-020-365617
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective clinical study aims to evaluate and compare the effectiveness of coronally advanced flap (CAF) and tunnel techniques, both combined with platelet-rich fibrin (PRF), in the treatment of multiple Miller Class I-II gingival recessions. Eleven participants with bilateral defects will be treated using a split-mouth design. Periodontal parameters will be assessed at baseline, 3 months, and 6 months.

Conditions

Gingival Recession

Keywords

gingival recessions; platelet rich fibrin; root coverage

Outcome Measures

Primary Outcomes (1)

• Change in Recession Height (RH)

  Recession height will be measured in millimeters from the cementoenamel junction to the gingival margin using a periodontal probe at baseline and 6 months postoperatively.

  Baseline and 6 Months

Secondary Outcomes (1)

• Change in Clinical Attachment Level (CAL)

  Baseline, 3 Months, and 6 Months

Study Arms (2)

CAF + PRF

EXPERIMENTAL

This group will receive coronally advanced flap (CAF) surgery combined with platelet-rich fibrin (PRF) for the treatment of multiple gingival recessions.

Procedure: CAF with PRF

Tunnel + PRF

EXPERIMENTAL

This group will receive tunnel surgical technique combined with platelet-rich fibrin (PRF) for the treatment of multiple gingival recessions.

Procedure: Tunnel with PRF

Interventions

CAF with PRF PROCEDURE

Coronally advanced flap technique will be performed to reposition the gingival margin coronally. Platelet-rich fibrin (PRF) membranes will be placed over the exposed root surfaces and stabilized with sutures.

CAF + PRF

Tunnel with PRF PROCEDURE

A tunnel or subgingival pouch will be created using microsurgical instruments without vertical incisions. Platelet-rich fibrin (PRF) membranes will be inserted into the tunnel and the gingival tissue will be advanced coronally and sutured to cover the recession.

Tunnel + PRF

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 18 years or older
• Systemically healthy individuals
• Presence of bilateral Miller Class I-II multiple gingival recessions
• Good oral hygiene and willingness to follow instructions
• Signed informed consent

You may not qualify if:

• Use of tobacco or smoking
• Pregnancy or lactation
• Presence of systemic diseases affecting periodontal health
• Use of medications that may affect healing (e.g., corticosteroids)
• Periodontal surgery in the same area within the last 6 months

Sponsors & Collaborators

• Pamukkale University: lead

Study Sites (1)

Pamukkale University, Faculty of Dentistry, Periodontology

Denizli, 20160, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Gingival Recession

Interventions

Prolactin-Releasing Hormone

Condition Hierarchy (Ancestors)

Gingival Diseases; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Periodontal Atrophy

Intervention Hierarchy (Ancestors)

Hypothalamic Hormones; Peptide Hormones; Hormones; Hormones, Hormone Substitutes, and Hormone Antagonists; Neuropeptides; Peptides; Amino Acids, Peptides, and Proteins; Nerve Tissue Proteins; Proteins

Study Officials

• Gizem TORUMTAY CİN, Assoc. Prof. Dr.

  Pamukkale University Faculty of Dentistry, Department of Periodontology

  STUDY DIRECTOR

Central Study Contacts

Necati Zavrak, RA

CONTACT

+905367401003; necatizvrk@gmail.com

Gizem Torumtay Cin, Assoc. Prof. Dr.

CONTACT

+905053913915; gyaprak_dt@hotmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Masking Details: The clinical examiner who recorded the outcome measures was blinded to the type of surgical technique applied on each side.
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc. Prof. Dr.

Model Details: Split-mouth randomized design. Each participant receives both interventions, one per side of the mouth.

Study Record Dates

• First Submitted: May 9, 2025
• First Posted: May 23, 2025
• Study Start: August 15, 2025
• Primary Completion: March 15, 2026
• Study Completion: March 15, 2026
• Last Updated: August 17, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)