Platelet Rich Fibrin in the Treatment of Multiple Gingival Recessions
Comparison of Platelet Rich Fibrin and Connective Tissue Graft in Treatment of Multiple Gingival Recessions
1 other identifier
interventional
26
1 country
1
Brief Summary
The aim of this randomized controlled clinical study is to evaluate and compare the effectiveness of platelet rich fibrin (PRF) and connective tissue grafts in the treatment of multiple gingival recessions.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started May 2012
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2013
CompletedFirst Submitted
Initial submission to the registry
December 17, 2013
CompletedFirst Posted
Study publicly available on registry
December 23, 2013
CompletedDecember 23, 2013
December 1, 2013
1.3 years
December 17, 2013
December 20, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Mean root coverage percentage
mean area of root coverage achieved by surgical root coverage therapy.
6 months
complete root coverage percentage
percentage of gingival recession defects completely covered by flaps after 6 months
6 months
Secondary Outcomes (2)
keratinized tissue width
6 months
gingival tissue thickness
6 months
Study Arms (2)
connective tissue graft
ACTIVE COMPARATORconnective tissue graft harvested from palatum of subjects and placed under modified coronally advanced flap
Platelet rich fibrin
EXPERIMENTALAutogenous platelet rich fibrin was obtained from subjects own blood samples after centrifugation. Platelet rich fibrin membranes were placed under modified coronally advanced flaps.
Interventions
Eligibility Criteria
You may qualify if:
- Two or more adjacent teeth with at least 2 mm Miller Class I gingival recessions at non-molar teeth
- Identifiable CEJ on all teeth
- Age ≥ 18
- Presence of tooth vitality and absence of restorations and superficial caries in the treatment area
- No past surgical treatment history of affected area.
- Gingival thickness ≥ 0,8 mm for recession areas.
- Sufficient palatal donor tissue for connective tissue harvesting.
You may not qualify if:
- Smoking
- Pregnancy or lactation
- Systematic diseases that may affect outcomes of periodontal therapy
- Self-reported antibiotic medication within three months
- Occlusal trauma in treatment site
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Ege Universitylead
Study Sites (1)
Ege University School of Dentistry Department of Periodontology
Izmir, Bornova, 35100, Turkey (Türkiye)
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Gül Atilla, Professor
Ege University School of Dentistry
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- PhD
Study Record Dates
First Submitted
December 17, 2013
First Posted
December 23, 2013
Study Start
May 1, 2012
Primary Completion
August 1, 2013
Study Completion
August 1, 2013
Last Updated
December 23, 2013
Record last verified: 2013-12