A Study to Assess the Efficacy and Safety of Verekitug in Participants With COPD
A Phase 2b Randomized, Double-blind, Placebo-controlled, Parallel-Group Study to Assess Efficacy and Safety of Verekitug (UPB-101) in Participants With Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)
2 other identifiers
interventional
666
23 countries
242
Brief Summary
The purpose of this study is to assess the efficacy and safety of verekitug (UPB-101) in participants with moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD), an inflammatory lung disease.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_2 chronic-obstructive-pulmonary-disease
Started Jul 2025
Typical duration for phase_2 chronic-obstructive-pulmonary-disease
242 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 9, 2025
CompletedFirst Posted
Study publicly available on registry
May 20, 2025
CompletedStudy Start
First participant enrolled
July 2, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
November 1, 2027
July 20, 2026
July 1, 2026
2.2 years
May 9, 2025
July 17, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Annualized rate of moderate or severe COPD exacerbation events
From Day 1 (Baseline) up to Week 108
Secondary Outcomes (5)
Change in pre-bronchodilator forced expiratory capacity in 1 second (FEV1)
From Day 1 (Baseline) to Week 60
Annualized rate of severe COPD exacerbation events
From Day 1 (Baseline) up to Week 108
Change in St. George's Respiratory Questionnaire (SGRQ) total score
From Day 1 (Baseline) to Week 60
Proportion of participants with SGRQ improvement of >4 points
At Week 60
Incidence of treatment-emergent adverse events and serious adverse events
From Day 1 (Baseline) up to Week 112
Study Arms (3)
Verekitug (UPB-101) 100 mg and Placebo
EXPERIMENTALParticipants will receive 0.5 milliliter (mL) of the formulated solution (containing 100 milligrams \[mg\] of verekitug \[UPB-101\]) and 2.0 mL of matching placebo subcutaneously in two separate injections every 12 weeks up to Week 96.
Verekitug (UPB-101) 400 mg and Placebo
EXPERIMENTALParticipants will receive 2.0 mL of the formulated solution (containing 400 mg of verekitug \[UPB-101\]) and 0.5 mL of matching placebo subcutaneously in two separate injections every 24 weeks up to Week 96. Participants will also receive 2.0 mL and 0.5 mL of matching placebo subcutaneously in two separate injections at Weeks 12, 36, 60 and 84 visits.
Placebo
PLACEBO COMPARATORParticipants will receive 0.5 mL of matching placebo and 2.0 mL of matching placebo subcutaneously in two separate injections every 12 weeks up to Week 96.
Interventions
Eligibility Criteria
You may qualify if:
- Physician diagnosis of COPD for \>12 months.
- Current or former smokers with a smoking history of 10 pack-years or more.
- Post-bronchodilator FEV1/ Forced Vital Capacity (FVC) ratio \<0.70 and predicted post-bronchodilator FEV1 \>30% and ≤80%.
- Modified Medical Research Council dyspnea scale Grade ≥2.
- Background triple therapy (Inhaled Corticosteroid \[ICS\], Long-Acting Beta Agonist \[LABA\], Long-Acting Muscarinic Antagonist \[LAMA\]) for 3 months before randomization with a stable dose of medications for 1 or more months prior to Visit 1.
- Are ≥80% compliant with background therapy during the screening period.
You may not qualify if:
- Moderate or severe exacerbation of COPD within 4 weeks prior to or during the screening period.
- Respiratory tract infection within 4 weeks prior to or during the screening period.
- Treatment with oxygen of \>4 liters/minute. Nocturnal oxygen use for sleep apnea is allowed.
- Systemic or biologic immunosuppressant therapy to treat inflammatory disease or autoimmune disease within 24 weeks or 5 half-lives prior to Visit 1, whichever is longer, with the exception of oral corticosteroids. Treatment with cyclophosphamide and rituximab within 12 months of Visit 1.
- Current diagnosis of asthma according to the 2023 Global Initiative for Asthma guidelines or other accepted guidelines
- History or evidence of a clinically meaningful pulmonary condition other than COPD (e.g., pulmonary fibrosis, sarcoidosis, interstitial lung disease, pulmonary hypertension, bronchiectasis, Churg-Strauss Syndrome) or another diagnosed pulmonary or systemic disease associated with elevated peripheral eosinophil counts.
- Chronic hypercapnia requiring Bilevel Positive Airway Pressure (BiPAP). Participants requiring BiPAP periodically for an acute COPD exacerbation are not excluded.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (242)
Kern Research Inc.
Bakersfield, California, 93301, United States
PulmoCrit Associates
Encino, California, 91436, United States
Torrance Clinical Research Institute
Lomita, California, 90717-2101, United States
Dream Team Clinical Research
Pomona, California, 91767, United States
Apex Clinical Research
San Diego, California, 92120, United States
Allianz Research Institute
Westminster, California, 92683, United States
D&H Doral Research Center, LLC
Doral, Florida, 33122, United States
Qway Research, LLC
Hialeah, Florida, 33010, United States
Finlay Medical Research
Miami, Florida, 33126, United States
MplusM - ITB Research
Miami, Florida, 33173, United States
Florida Institute for Clinical Research,LLC
Orlando, Florida, 32825, United States
Velocity Clinical Research-Savannah - Internal Medicine
Savannah, Georgia, 31406, United States
Christie Clinic, LLC
Champaign, Illinois, 61820, United States
Velocity Clinical Research-Rockville
Rockville, Maryland, 20854, United States
Chesapeake Clinical Research, Inc
White Marsh, Maryland, 21162, United States
HealthPartners
Saint Paul, Minnesota, 55130, United States
American Health Research, Inc.
Charlotte, North Carolina, 28277, United States
Velocity Clinical Research, Anderson
Anderson, South Carolina, 29621, United States
SleepMed Inc.
Columbia, South Carolina, 29201, United States
Velocity Clinical Research, Gaffney
Greenville, South Carolina, 29615, United States
Velocity Clinical Research, Spartanburg - Pulmonology
Spartanburg, South Carolina, 29303, United States
Velocity Clinical Research- Union
Union, South Carolina, 29379, United States
El Paso Pulmonary Association
El Paso, Texas, 79902, United States
Victorium Clinical Research
Houston, Texas, 77024, United States
Synergy Groups Medical LLC
Houston, Texas, 77036, United States
Synergy Groups Medical LLC
Houston, Texas, 77061, United States
Metroplex Pulmonary and Sleep Center
McKinney, Texas, 75069, United States
Synergy Groups Medical LLC
Missouri City, Texas, 77459, United States
Velocity Clinical Research - Suffolk
Suffolk, Virginia, 23435, United States
CARE - Centro de Alergia y Enfermedades Respiratorias
Buenos Aires, Buenos Aires, C1414AIF, Argentina
Consultorios Médicos Dr. Doreski
Buenos Aires, Buenos Aires, C1426ABP, Argentina
Centro de Medicina Respiratoria
Concepción del Uruguay, Entre Ríos Province, 3260, Argentina
Fundacion Scherbovsky
Mendoza, Mendoza Province, 5500, Argentina
Fundacion Estudios Clinicos (FECLIN)
Rosario, Santa Fe Province, 2000, Argentina
Instituto Médico Fundación Grupo Colaborativo Rosario Invest
Rosario, Santa Fe Province, 2000, Argentina
Medical Center Pulmo-2018 EOOD
Haskovo, Haskovo, 6300, Bulgaria
Medical Center Medconsult Pleven, Lovech branch
Lovech, Lovech, 5500, Bulgaria
MEDICAL CENTER HERA EOOD; Office of Pulmonology and Phtisiatrics
Montana, Montana, 3400, Bulgaria
SHLTTRPD "Sveta Petka Balgarska" EOOD
Velingrad, Pazardzhik, 4600, Bulgaria
Specialized Hospital For Active Treatment Of Pulmonary Diseases Sv.Panteleymon EOOD
Dupnitsa, Pernik, 2307, Bulgaria
Dr. Filip Shterev IAPSMCPP EOOD
Plovdiv, Plovdiv, 4000, Bulgaria
Medical Center Etika Ambulatory For Specialized Outpatient Medical Care OOD
Plovdiv, Plovdiv, 4000, Bulgaria
Multiprofile Hospital for Active Treatment "St. Panteleimon "- Plovdiv
Plovdiv, Plovdiv, 4004, Bulgaria
Medical Center Prolet EOOD - Pulmonary, Allergy Diseases
Rousse, Ruse, 7002, Bulgaria
Specialized Hospital For Active Treatment Of Pneumo-Phthisiatric Diseases Dr. Dimitar Gramatikov-Ruse EOOD
Rousse, Ruse, 7002, Bulgaria
Diagnostic consultative center 1 -Sliven
Sliven, Sliven, 8800, Bulgaria
MHAT Sliven to MMA Sofia
Sliven, Sliven, 8800, Bulgaria
Medical Center Excelsior OOD, Base 2
Sofia, Sofia, 1111, Bulgaria
Acibadem City Clinic Tokuda University Hospital EAD
Sofia, Sofia, 1407, Bulgaria
First Multiprofile Hospital for Active Treatment - Sofia
Sofia, Sofia-Grad, 1142, Bulgaria
Specialized Hospital For Active Treatment Of Pulmonary Diseases - Sofia EOOD
Sofia, Sofia-Grad, 1202, Bulgaria
National Multiprofile Transport Hospital (NMTB) - Internal Diseases
Sofia, Sofia-Grad, 1233, Bulgaria
Medical Center Excelsior OOD, Base 1
Sofia, Sofia-Grad, 1407, Bulgaria
Medical Center Hera
Sofia, Sofia-Grad, 1510, Bulgaria
DCC Convex EOOD
Sofia, Sofia-Grad, 1680, Bulgaria
Medical Center for Outpatient Care Preventsia 2000
Stara Zagora, Stara Zagora, 6000, Bulgaria
Medical Center - Zdrave1
Kozloduy, Vratsa, 3320, Bulgaria
Clinica Fundacion Medica San Cristobal
Vitacura, Santiago Metropolitan, 7630226, Chile
Centro de Investigación de Enfermedades Respiratorias e Inmunológicas
Viña del Mar, Valparaiso, 2520000, Chile
EDUMED, s.r.o
Broumov, Hradec Králové Region, 550 01, Czechia
Plicni ambulance Alveolus s.r.o.
Poruba, Moravian-Silesian Region, 70800, Czechia
MEDICON a.s. - Plicni oddeleni
Prague, Praha, Hlavní Mesto, 14000, Czechia
Privatni plicni ambulance, s.r.o.
Prague, Praha, Hlavní Mesto, 19061, Czechia
Plicni ambulance Rokycany
Rokycany, Rokycany, 33701, Czechia
MUDr. Pavlisova Ilona s.r.o.
Miroslav, South Moravian, 671 72, Czechia
MUDr. I. Cierna Peterova s.r.o.
Brandýs nad Labem, Stredoceský Kraj, 25001, Czechia
Plicni ambulance Kralupy s.r.o.
Kralupy nad Vltavou, Stredoceský Kraj, 278 01, Czechia
Plicni stredisko Teplice s.r.o. - Plicni ordinace
Teplice, Ústí nad Labem Region, 41501, Czechia
Pneumologie Varnsdorf s.r.o.
Varnsdorf, Ústí nad Labem Region, 40747, Czechia
LTD "High Technology Hospital Medcenter"
Batumi, Adjara, 6010, Georgia
LTD Clinic Rustavi
Rustavi, Hvemo Kartli, 3700, Georgia
A. Aladashvili clinic LLC
Tbilisi, K'alak'i T'bilisi, 102, Georgia
LTD "Israel-Georgian Medical Research Clinic Healthycore"
Tbilisi, K'alak'i T'bilisi, 112, Georgia
Tbilisi State Medical University and Ingorokva High Medical Technology University Clinic
Tbilisi, K'alak'i T'bilisi, 144, Georgia
Center of Allergy and Immunology - Allergy/Immunology-Reumatology
Tbilisi, K'alak'i T'bilisi, 159, Georgia
LTD "Emergency Cardiology Center named by Acad.G.Chapidze"
Tbilisi, K'alak'i T'bilisi, 159, Georgia
Ltd Diacor
Tbilisi, K'alak'i T'bilisi, 159, Georgia
LTD MARNECOR - Internal Medicine
Marneuli, Kvemo Kartli, 3000, Georgia
Gemeinschaftspraxis Rolke / Rückert
Aschaffenburg, Bavaria, 63739, Germany
Pneumologie, Schlafmedizin und Onkologie am Diako
Augsburg, Bavaria, 86150, Germany
CIMS Studienzentrum Bamberg
Bamberg, Bavaria, 96049, Germany
Asklepios Lungenklinik Gauting GmbH - Zentrum für Pneumologie und Thoraxchirurgie
München, Bavaria, 82131, Germany
MECS GmbH
Cottbus, Brandenburg, 3050, Germany
ME Clinical Respiratory Research
Hamburg, Free and Hanseatic City of Hamburg, 22299, Germany
Pneumostudien Darmstadt GmbH
Darmstadt, Hesse, 64283, Germany
IKF Pneumologie GmbH & Co. KG
Frankfurt am Main, Hesse, 60596, Germany
Ballenberger, Freytag, Wenisch
Neu-Isenburg, Hesse, 63263, Germany
Pneumologische Praxis und Schlaflabor - Lutz Volgmann
Hanover, Lower Saxony, 30167, Germany
Studienzentrum Dr.med. Christian Schlenska - Pneumologie/Allergologie/Innere Medizin
Peine, Lower Saxony, 31224, Germany
Framol-Med GmbH
Rheine, North Rhine-Westphalia, 48431, Germany
Gemeinschaftspraxis Franz, Weber
Witten, North Rhine-Westphalia, 58452, Germany
IKF Pneumologie GmbH & Co. KG
Mainz, Rhineland-Palatinate, 55128, Germany
Pneumologicum-Halle - Pulmonary
Halle, Saxony-Anhalt, 6108, Germany
Velocity Clinical Research Germany GmbH
Lübeck, Schleswig-Holstein, 23552, Germany
Studienpraxis Berlin-Brandenburg
Berlin, State of Berlin, 10119, Germany
Lungenpraxis Hohenzollerndamm
Berlin, State of Berlin, 10717, Germany
Velocity Clinical Research Germany GmBH
Berlin, State of Berlin, 10787, Germany
MECS Research GmbH
Berlin, State of Berlin, 12203, Germany
Infer-Med Kft.
Pécs, Baranya, 7635, Hungary
Koch Róbert Kórház és Rendel?intézet
Edelény, Borsod-Abauj Zemplen county, H-3780, Hungary
ClinExpert Kft.
Budapest, Budapest, 1033, Hungary
Pulmo Protect Kft.
Budapest, Budapest, 1044, Hungary
Kek Pont Aquagyogyaszat Kft.
Kecskemét, Bács-Kiskun county, 6000, Hungary
Aranyklinika Kft
Bordány, Csongrád megye, 6720, Hungary
Debreceni Egyetem Klinikai Központ - Tüdőgyógyászati Klinika
Debrecen, Debrecen, H-4012, Hungary
Szalay Janos Rendelointezet
Hajdúnánás, Hajdú-Bihar, 4080, Hungary
Puspokladanyi Egeszsegugyi Szolgaltato Nonprotfit Kft
Püspökladány, Heves County, 4150, Hungary
Erzsebet Gondozohaz Kft.
Gödöllő, Pest County, 2100, Hungary
Farkasgyepui Tudogyogyintezet
Farkasgyepű, Veszprém megye, 8582, Hungary
Astar Prime Hospitals - Internal Medicine
Hyderabad, Andhra Pradesh, 500036, India
A.C. Subba Reddy Government Medical College (ACSR) - Pulmonary
Nellore, Andhra Pradesh, 524004, India
Siddhartha Medical College
Vijayawada, Andhra Pradesh, 520008, India
Medanta Medicity
Gurgaon, Haryana, 122001, India
Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences (PGIMS) - Pandit Bhagwat Dayal Sharma
Rohtak, Haryana, 124001, India
Rajarshi Chhatrapati Shahu Maharaj (RCSM) Government Medical College & CPR Hospital
Kolhāpur, Maharashtra, 416002, India
Shree Hospital & Critical Care Centre
Nagpur, Maharashtra, 440009, India
Sir Ganga Ram Hospital (SGRH) - Gastroenterology and Hepatology
New Delhi, National Capital Territory of Delhi, 110 001, India
S.P Medical College and Group of Hospitals, Bikaner
Bikaner, Rajasthan, 334001, India
Shri Mahant Indiresh Hospital
Dehradun, Uttarakhand, 248001, India
JNMC
Belgaum, West Bengal, 590010, India
NRS Medical College
Kolkata, West Bengal, 700014, India
Connolly Hospital
Dublin, Dublin, D15 X40D, Ireland
Tallaght University Hospital
Tallaght, Dublin, D24 NR0A, Ireland
Our Lady of Lourdes Hospital
Drogheda, Louth, A92VW28, Ireland
Veselibas Centru apvieniba AS, Dubultu poliklinika
Jūrmala, Jūrmala, LV-2010, Latvia
Liepaja Regional Hospital
Liepāja, Liepaja, LV-3414, Latvia
Pauls Stradins Clinical University Hospital - Center of Lung Diseases
Riga, Riga, LV-1002, Latvia
SIA "Profesora Skrides Sirds klīnika"
Riga, Riga, LV-1013, Latvia
Hospital of Lithuanian University of Health Sciences Kauno Klinikos
Kaunas, Kaunas County, LT 50161, Lithuania
Lithuanian University of Health Sciences Kaunas Hospital
Kaunas, Kaunas County, LT-47116, Lithuania
Republic Klaipeda Hospital
Klaipėda, Klaipėda County, LT-92231, Lithuania
Institut Perubatan Respiratori
Kuala Lumpur, Kuala Lumpur, 53000, Malaysia
Universiti Malaya Medical Centre
Kuala Lumpur, Kuala Lumpur, 59100, Malaysia
Hospital Pulau Pinang
George Town, Pulau Pinang, 10990, Malaysia
Thomson Hospital Kota Damansara
Petaling Jaya, Selangor, 47500, Malaysia
Universiti Teknologi MARA
Shah Alam, Selangor, 68100, Malaysia
Marilao Saint Michael Family Hospital, Inc. - Research Room
Marilao, Bulacan, 3019, Philippines
CARE Clinical Trial Group Inc.
Dasmariñas, Cavite, 4114, Philippines
De Asis Medical Clinic (Norzel Medical and Diagnostic Clinic)
Cebu, Cebu, 6000, Philippines
Perpetual succour hospital of Cebu INC
Cebu, Cebu, 6000, Philippines
Iloilo Doctors' Hospital Inc.
Iloilo City, Iloilo, 5000, Philippines
Health Cube Medical Clinics
Mandaluyong, National Capital Region, 1552, Philippines
Centrum Medyczne Pratia Bydgoszcz
Bydgoszcz, Greater Poland Voivodeship, 85-796, Poland
Specjalistyczna Przychodnia Lekarska Alergo - Med Sp. z o.o.
Poznan, Greater Poland Voivodeship, 61-578, Poland
Centrum Medyczne ALL-MED
Krakow, Lesser Poland Voivodeship, 30-033, Poland
Pratia MCM Kraków
Krakow, Lesser Poland Voivodeship, 30-727, Poland
Clinical Best Solutions
Lublin, Lubusz Voivodeship, 20-078, Poland
Twoja Przychodnia Nowosolskie Centrum Medyczne Sp. z o. o.
Nowa Sól, Lubusz Voivodeship, 67-100, Poland
Velocity Skierniewice Sp. z o.o.
Skierniewice, Lódzkie, 96-100, Poland
RCMed Oddzial Sochaczew
Sochaczew, Masovian Voivodeship, 96-500, Poland
Prywatny Gabinet Lekarski
Rzeszów, Podkarpackie Voivodeship, 35-051, Poland
EMED Centrum Uslug Medycznych Ewa Smialek
Rzeszów, Podkarpackie Voivodeship, 35-205, Poland
Centrum Medycyny Oddechowej, Mroz Spolka Jawna
Bialystok, Podlaskie Voivodeship, 15-044, Poland
ClinicMed Daniluk, Nowak Sp. Komandytowa
Bialystok, Podlaskie Voivodeship, 15-879, Poland
Uniwersyteckie Centrum Kliniczne - Klinika Alergologii
Gdansk, Pomeranian Voivodeship, 80-214, Poland
Centrum Medyczne Pratia Katowice
Katowice, Warmian-Masurian Voivodeship, 40-081, Poland
Twoja Przychodnia Szczecinskie Centrum Medyczne Sp. z o. o.
Szczecin, West Pomeranian Voivodeship, 71-434, Poland
Centrul Medical de Diagnostic si Tratament Ambulator Neomed - Multiple Specialties
Brasov, Brașov County, 500283, Romania
Centrul Medical Sana
Bucharest, Bucharest, 11025, Romania
Medsana CM Cotroceni Pulmonology
Bucharest, Bucharest, 50521, Romania
Rimmed Centru Medical Pulmonology
Bucharest, Bucharest, 61334, Romania
Anima Specialty Medical Services
Bucharest, Bucharest, 616962, Romania
CM Pneumologie Dr Mincu Bogdan
Cluj-Napoca, Cluj, 400275, Romania
Sp Pneumoftizio Leon Daniello CJ
Cluj-Napoca, Cluj, 400371, Romania
Sp.Clinic Pneumo Constanta Pulmon 2
Palazu Mare, Constanța County, 900002, Romania
Angisan Grup
Bragadiru, Ilfov, 77025, Romania
Fundatia Dr. Victor Babes
Bucuresti, Ilfov, 30303, Romania
Clintrial Medical Center
Dobrosloveni, Olt, 237143, Romania
Sp Dr Victor Babes Timisoara Pulmon
Timișoara, Timiș County, 300310, Romania
Institute for Pulmonary Diseases of Vojvodina, Clinic for Pulmonary Oncology
Kamenitz, Vojvodina, 21204, Serbia
FNsP F.D.R. Banska Bystrica - Pneumologie a ftizeologie
Banská Bystrica, Banská Bystrica Region, 97517, Slovakia
Pneumomed s.r.o. - Pneumo-Alergo Centrum
Bratislava, Bratislava Region, 85101, Slovakia
MEDEKA s.r.o. - Pneumologia a ftizeologia
Košice, Košice Region, 040 01, Slovakia
Plucna ambulancia Hrebenar s.r.o.
Spišská Nová Ves, Košice Region, 052 01, Slovakia
ZAPA JJ s.r.o. - Pneumologia a ftizeologia
Levice, Nitra Region, 934 01, Slovakia
DIONEA, s.r.o. - Ambul. pneumologie
Nové Zámky, Nitra Region, 940 01, Slovakia
INSPIRO s.r.o. - MUDr. Golubov Alexander - Pneumologia a ftizeologia
Humenné, Presov, 066 01, Slovakia
PAFA, s.r.o.
Kežmarok, Presov, 6001, Slovakia
Yonsei University, Wonju Severance Christian Hospital - Pulmonology
Wŏnju, Gang'Weondo [Kang-won-do], 26426, South Korea
Seoul National University Bundang Hospital - Pulmonology
Seongnam-si, Gyeonggido [Kyonggi-do], 13620, South Korea
The Catholic University of Korea, Incheon St. Mary's Hospital
Incheon, Incheon Gwang'Yeogsi [Inch'n-Kwangyokshi], 21431, South Korea
Korea University Anam Hospital - Pulmonology
Seoul, Seoul, 2841, South Korea
Konkuk University Medical Center
Seoul, Seoul, 5030, South Korea
Kyung Hee Universtiy Hospital
Seoul, Seoul Teugbyeolsi [Seoul-T'Ukpyolshi], 2447, South Korea
Severance Hospital, Yonsei University Health System - Pulmonary
Seoul, Seoul Teugbyeolsi [Seoul-T'Ukpyolshi], 3722, South Korea
Eunpyeong St. Mary's Hospital
Seoul, Seoul Teugbyeolsi, 3312, South Korea
Hospital Universitario Son Espases
Palma de Mallorca, Balearic Islands, 7120, Spain
Hospital Sierrallana - Neumologia
Torrelavega, Cantabria, 39300, Spain
Hospital De Jerez De La Frontera
Jerez de la Frontera, Cádiz, 11407, Spain
Hospital San Pedro de Alcántara
Cáceres, Extremadura, 10003, Spain
Hospital Universitario Virgen de las Nieves
Granada, Granada, 18014, Spain
Fundacion Jimenez Diaz
Madrid, Madrid, 28040, Spain
Hospital Universitario La Paz - Neumologia
Madrid, Madrid, 28046, Spain
Hospital Universitario Quironsalud Madrid
Pozuelo de Alarcón, Madrid, 28223, Spain
Vithas Xanit International Hospital - Gastroenterology
Benalmádena, Málaga, 29630, Spain
Hospital Quirónsalud Marbella
Marbella, Málaga, 29603, Spain
Hospital Universitario Virgen de la Victoria
Málaga, Málaga, 29010, Spain
Clinica Universidad de Navarra - Neumología
Pamplona, Navarre, 31008, Spain
Complejo Hospitalario de Navarra
Pamplona, Navarre, 31008, Spain
Hospital Universitario Virgen del Rocio
Seville, Sevilla, 41013, Spain
Hospital Clinico Universitario De Valencia - Neumologia
Valencia, Valencia, 46010, Spain
KMU Chung-Ho Memorial Hospital
Kaohsiung City, Kaohsiung, 80756, Taiwan
Chang Gung Medical Foundation - Kaohsiung Chang Gung Memorial Hospital - Hemato-Oncology
Kaohsiung City, Kaohsiung, 833401, Taiwan
Taichung Veterans General Hospital - Chest Medicine
Taichung, Taichung, 407219, Taiwan
Kuang Tien General Hospital - XiangShang
Taichung, Taichung, 433, Taiwan
Chi Mei Medical Center - YongKang - Pulmonary Medicine
Tainan, Tainan, 71004, Taiwan
Taipei Medical University - Taipei Medical University Hospital - Internal Medicine
Taipei, Taipei, 110, Taiwan
Chang Gung Medical Foundation - LinKou Chang Gung Memorial Hospital - Pulmonary
Taoyuan, Taoyuan, 333423, Taiwan
National Taiwan University Hospital - Yunlin Branch - Douliou
Douliu, Yunlin, 640203, Taiwan
KNP "Cherkaska oblasna likarnia"
Cherkasy, Cherkasy Oblast, 18009, Ukraine
KNP"Ts inf.zakhv.Iv-Frank.obl.rady"
Ivano-Frankivsk, Ivano-Frankivsk Oblast, 76018, Ukraine
Likuv.-diahn. tsentr Sviatoho Luky
Ivano-Frankivsk, Ivano-Frankivsk Oblast, 76019, Ukraine
MTs "Universalna klinika "Oberih"
Kyiv, Kyiv Oblast, 2000, Ukraine
DU "NNTs im. Yanovskoho"
Kyiv, Kyiv Oblast, 3038, Ukraine
Klin.likarnia na zal.transporti №2
Kyiv, Kyiv Oblast, 3049, Ukraine
DU "NNTs im. Yanovskoho"
Kyiv, Luhansk Oblast, 3038, Ukraine
MTs "Klinika Hospodarskykh"
Ternopil, Ternopil Oblast, 46002, Ukraine
Medychnyi tsentr "Puls"
Vinnytsia, Vinnytsia Oblast, 21001, Ukraine
Uzh.miska bahatoprofilna klin.lik.
Uzhhorod, Zakarpattia Oblast, 88009, Ukraine
Lik.z nevidkl. staniv ta ekstr.dop.
Uzhhorod, Zakarpattia Oblast, 88017, Ukraine
KNP "Likarnia №1" Zhytom.misk.rady
Zhytomyr, Zhytomyr Oblast, 10002, Ukraine
Bioluminux Clinical Research
Milton Keynes, Bedfordshire, MK15 0DU, United Kingdom
Synexus Midlands Clinical Research Centre
Edgbaston, Birmingham, B15 2SQ, United Kingdom
Velocity Clinical Research - High Wycombe
High Wycombe, Buckinghamshire, HP11 2QW, United Kingdom
Royal Primary Care - Ashgate
Chesterfield, Derbyshire, S40 4AA, United Kingdom
Ashburton Surgery
Newton Abbot, Devon, TQ13 7AP, United Kingdom
Velocity Romford
Romford, Essex, RM1 3PJ, United Kingdom
NHS Greater Glasgow & Clyde - Gartnavel General Hospital - Respiratory
Glasgow, Glasgow City, G12 0YN, United Kingdom
Panthera Biopartners - Glasgow
Glasgow, Glasgow City, G51 4TY, United Kingdom
Panthera Biopartners - Preston
Preston, Lancashire, PR2 9QB, United Kingdom
Leeds Teaching Hospitals NHS Trust - St James' University Hospital
Leeds, Leeds, LS9 7TF, United Kingdom
FutureMeds Wirral
Metropolitan Borough of Wirral, Liverpool, CH62 6EE, United Kingdom
Panthera Biopartners - North London
Enfield, London, EN3 4GS, United Kingdom
Panthera Biopartners - Manchester
Rochdale, Manchester, OL11 4AU, United Kingdom
Lakeside Healthcare
Corby, Northamptonshire, NN17 2UR, United Kingdom
Futuremeds - Glasgow
Glasgow, Scotland, G20 7BE, United Kingdom
Panthera Biopartners - Sheffield
Sheffield, Sheffield, S2 5FX, United Kingdom
NHS Tayside - Ninewells Hospital
Dundee, United Kingdom, DD1 9SY, United Kingdom
FutureMeds - Newcastle
Newcastle, United Kingdom, NE6 1SG, United Kingdom
Royal Berkshire Hospital
Reading, United Kingdom, RG1 5AN, United Kingdom
Futuremeds -Teesside
Metropolitan Borough of Wirral, Wirral, TS19 8PE, United Kingdom
Panthera Biopartners - York
York, York, YO24 4LJ, United Kingdom
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Justin Salciccioli, MD
Upstream Bio
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 9, 2025
First Posted
May 20, 2025
Study Start
July 2, 2025
Primary Completion (Estimated)
October 1, 2027
Study Completion (Estimated)
November 1, 2027
Last Updated
July 20, 2026
Record last verified: 2026-07
Data Sharing
- IPD Sharing
- Will not share