The Correlation of Clinical and Ultrasonographic Findings in Dorsoradial Wrist Pain Patients: Cross Sectional Study

NCT06980779 | Completed

• 1 other identifier: E-10840098-202.3.02-3745
• Study Type: observational
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate the correlation between ultrasonographic and clinical findings in dorsoradial wrist pain. There are several etiologies for dorsoradial wrist pain, including carpometacarpal joint arthritis, De Quervain's tenosynovitis, proximal and distal intersection syndrome, Wartenberg syndrome, and ganglion cysts. In these clinical scenarios, certain physical examination tests are utilized, such as the Finkelstein test for De Quervain's tenosynovitis; however, this test may also yield positive results in cases of severe joint arthritis. Ultrasonography is proposed as a complementary tool for differential diagnosis. The investigators aim to examine the correlation between clinical test results and ultrasonographic parameters such as tendon thickness in the first extensor compartment, carpometacarpal joint synovitis, cortical irregularities, and the presence of osteophytes. Functional status will be assessed using the QuickDASH and FIHOA questionnaires.

Conditions

Carpometacarpal (CMC) Joint Arthritis; Ganglion Cyst; De Quervain Disease; Radial Neuropathy

Keywords

carpometacarpal joint arthritis; ultrasonography; dorsoradial wrist pain; de Quervain disease; intersection syndrome; ganglion cyst

Outcome Measures

Primary Outcomes (4)

• Odds Ratio of First Extensor Compartment Tendon Sheath Thickness Associated with De Quervain Disease

  To quantify the association between increased tendon sheath thickness and clinical diagnosis of De Quervain tenosynovitis using logistic regression analysis.

  At the time of enrollment

• Odds Ratio of Synovial Hypertrophy in CMC Joint Associated with Carpometacarpal Arthritis

  To assess the strength of association between ultrasonographic synovial hypertrophy and clinical diagnosis of carpometacarpal joint arthritis.

  At the time of enrollment

• Sensitivity of Ultrasonographic Parameters for Diagnosing Dorsoradial Wrist Pathologies

  To assess the diagnostic sensitivity of individual ultrasonographic findings (e.g., tendon sheath thickness, synovial hypertrophy) for detecting De Quervain tenosynovitis and CMC arthritis.

  At the time of enrollment

• Specificity of Ultrasonographic Parameters for Diagnosing Dorsoradial Wrist Pathologies

  To assess the diagnostic specificity of individual ultrasonographic findings for identifying De Quervain tenosynovitis and CMC arthritis.

  At the time of enrollment

Interventions

ultrasonographic examination OTHER

ultrasonographic examination

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

patients who referred physical theraphy and rehabilitation and orthopedia clinics with dorsoradial wrist and thumb pain

You may qualify if:

• pain in dorsoradial wrist

You may not qualify if:

• known rheumatological disease
• history of forearm, wrist, hand fracture
• history of forearm, wrist, hand operation
• mental retardation
• history of major trauma in forearm, wrist and hand
• fibromyalgia

Sponsors & Collaborators

• Fatih Sultan Mehmet Training and Research Hospital: lead

Study Sites (1)

University of Health Sciences, FSM Training and Research Hospital, Istanbul

Istanbul, ataşehir, 34752, Turkey (Türkiye)

Location

Related Publications (3)

• McBain B, Rio E, Cook J, Grabinski R, Docking S. Diagnostic accuracy of imaging modalities in the detection of clinically diagnosed de Quervain's syndrome: a systematic review. Skeletal Radiol. 2019 Nov;48(11):1715-1721. doi: 10.1007/s00256-019-03195-z. Epub 2019 Mar 19.

  PMID: 30888457 BACKGROUND

• Montechiarello S, Miozzi F, D'Ambrosio I, Giovagnorio F. The intersection syndrome: Ultrasound findings and their diagnostic value. J Ultrasound. 2010 Jun;13(2):70-3. doi: 10.1016/j.jus.2010.07.009. Epub 2010 Sep 19.

  PMID: 23396515 BACKGROUND

• Look N, Mcnulty M, Rodriguez-Fontan F, Fenoglio AK. Radial-sided wrist pain differentials: presentation, pathoanatomy, diagnosis, and management. Medicina (B Aires). 2023;83(1):96-107.

  PMID: 36774602 BACKGROUND

MeSH Terms

Conditions

Capillary Malformations, Congenital, 1; Ganglion Cysts; De Quervain Disease; Radial Neuropathy

Condition Hierarchy (Ancestors)

Cysts; Neoplasms; Mucinoses; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Tendon Entrapment; Tendinopathy; Muscular Diseases; Musculoskeletal Diseases; Mononeuropathies; Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases

Study Officials

• Ilkyaz Yağar, Resident

  University of Health Sciences, FSM Training and Research Hospital, Istanbul

  PRINCIPAL INVESTIGATOR

• Esra Giray, Associated Professor

  University of Health Sciences, FSM Training and Research Hospital, Istanbul

  STUDY DIRECTOR

• Aslınur Keleş

  University of Health Sciences, FSM Training and Research Hospital, Istanbul

  STUDY CHAIR

• Feyza Unlu Ozkan, Professor

  University of Health Sciences, FSM Training and Research Hospital, Istanbul

  STUDY CHAIR

• Ilknur Aktas, Professor

  University of Health Sciences, FSM Training and Research Hospital, Istanbul

  STUDY CHAIR

• Ozge Gulsum Illeez, Associated Professor

  University of Health Sciences, FSM Training and Research Hospital, Istanbul

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Doctor

Study Record Dates

• First Submitted: March 23, 2025
• First Posted: May 20, 2025
• Study Start: July 29, 2024
• Primary Completion: October 6, 2024
• Study Completion: October 6, 2024
• Last Updated: May 20, 2025

Record last verified: 2024-06

Locations

TU (1)