The Relation Between Placental Volume at the 1st Trimester and Perinatal Prognosis

NCT05429242 | Completed

• 1 other identifier: SiirtUNIV
• Study Type: observational
• Target: 360
• Locations: 1 country
• Sites: 1

Brief Summary

It has been known for years that placental transport and endocrine and metabolic functions of the placenta are the main determinants of fetal nutrition and homeostasis. And placental capacity is roughly related to the weight of this organ. It has long been understood that placental weight at birth is also positively associated with birth weight. Since the 1970s, it has been possible to assess the size of the placenta in early pregnancy using two-dimensional (2D) ultrasonography (USG). Since then, it has been estimated that placental size is associated with fetal development. However, the difficulty in defining the required sonographic planes due to the technology of that time-limited the usefulness of this technique. As studies on this subject increase with the development of technology, it has now been shown that low placental volume at 11-13 weeks is associated with babies small for gestational age (SGA), fetal growth restriction, and preeclampsia. Pregnancy complications place a severe burden on the health system. Detection of these complications in the early period will prevent maternal and fetal mortality and morbidity. A relationship that predicts obstetric, fetal, and perinatal risks with placental thickness and width measurement with USG, a non-invasive method, in an early period such as the 1st trimester, will enable a proactive approach to complications. In our study, the investigators plan to present the perinatal results they obtained rather than investigating a specific relationship. The investigators think that the results of their study will make a profound contribution to the literature.

Conditions

Pregnancy Complications; Perinatal Problems; Maternal-Fetal Relations

Keywords

placental volume; perinatal prognosis; first trimester; pregnancy

Outcome Measures

Primary Outcomes (4)

• Placental thickness in millimetres and pregnancy outcomes

  The relationship between placental volume in the 1st trimester and perinatal prognosis will be tried to be determined.

  From the 1.st trimester of pregnancy up to the first month after birth ( the perinatal period,(( about 7 months ))

• Pregnancy outcomes

  Gestational age in weeks during delivery

  Pregnancy Week at the time of birth from the first three -month period of pregnancy (about 7 months)

• Pregnancy outcomes

  Fetal weight in grams

  Fetal weight at the time of birth from the first three -month period of pregnancy (about 7 months)

• Pregnancy outcomes

  APGAR scores in numerical values

  At the first minute and 5th minute after delivery

Interventions

Ultrasonographic examination OTHER

Measurement of placental volume at the first trimester of pregnancy by using ultrasound.

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Pregnant women over the age of 18 and at 11-14 weeks of pregnancy

You may qualify if:

• \>18 years of age
• st trimester pregnancy

You may not qualify if:

• history of chronic hypertension
• history of pre gestational diabetes
• history of chronic diseases
• excessive consumption of alcohol
• smoking pregnants
• kidney disorders

Sponsors & Collaborators

• Siirt University: lead

Study Sites (1)

Siirt Üniversity Medical Faculty

Siirt, 56000, Turkey (Türkiye)

Location

Related Publications (3)

• Vachon-Marceau C, Demers S, Markey S, Okun N, Girard M, Kingdom J, Bujold E. First-trimester placental thickness and the risk of preeclampsia or SGA. Placenta. 2017 Sep;57:123-128. doi: 10.1016/j.placenta.2017.06.016. Epub 2017 Jun 17.

  PMID: 28864000 BACKGROUND

• Effendi M, Demers S, Giguere Y, Forest JC, Brassard N, Girard M, Gouin K, Bujold E. Association between first-trimester placental volume and birth weight. Placenta. 2014 Feb;35(2):99-102. doi: 10.1016/j.placenta.2013.11.015. Epub 2013 Dec 3.

  PMID: 24345759 BACKGROUND

• Farina A. Systematic review on first trimester three-dimensional placental volumetry predicting small for gestational age infants. Prenat Diagn. 2016 Feb;36(2):135-41. doi: 10.1002/pd.4754. Epub 2016 Jan 19.

  PMID: 26618611 BACKGROUND

MeSH Terms

Conditions

Pregnancy Complications

Condition Hierarchy (Ancestors)

Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases

Study Officials

• Şerif Aksin, Assoc.Prof

  Siirt University Medical Faculty Obstetrics and Gynecology Departmant

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: associate professor

Study Record Dates

• First Submitted: June 11, 2022
• First Posted: June 23, 2022
• Study Start: June 11, 2022
• Primary Completion: April 15, 2023
• Study Completion: April 15, 2023
• Last Updated: April 25, 2023

Record last verified: 2023-04

Locations

TU (1)