Post-Stroke Aphasia TMS

NCT06974279 | Recruiting FDA Device

• 1 other identifier: PRO00053951
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The investigator proposes to examine the effects of excitatory transcranial magnetic stimulation (TMS) combined with semantic feature analysis (SFA) language therapy to improve word-finding abilities in stroke survivors with aphasia (SWA).

Conditions

Aphasia; Stroke; Language

Keywords

Aphasia; Stroke; Language; TMS

Outcome Measures

Primary Outcomes (1)

• Accuracy on a picture naming test

  Changes in accuracy on untrained stimuli after SFA+TMS compared between groups (precision, control).

  immediately after and 8-12 weeks after last SFA+TMS treatment

Study Arms (2)

Precision TMS

ACTIVE COMPARATOR

SFA will be administered immediately after precision TMS

Device: Precision TMS with SFA

Control TMS

PLACEBO COMPARATOR

SFA will be administered immediately after control TMS

Device: Control TMS with SFA

Interventions

Precision TMS with SFA DEVICE

Excitatory TMS delivered using a precision site finding approach and intermittent theta burst stimulation protocol

Precision TMS

Control TMS with SFA DEVICE

Excitatory TMS using intermittent theta burst stimulation delivered to a control vertex site.

Control TMS

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosed with left hemisphere stroke
• Consent date \>= 1 month after stroke onset
• Fluent in English
• years of age or older

You may not qualify if:

• Severe cognitive, auditory or visual impairments that would preclude cognitive and language testing
• Presence of major untreated or unstable psychiatric disease (e.g. schizophrenia, bipolar disease)
• A chronic medical condition that is not treated or is unstable
• The presence of cardiac stimulators or pacemakers or intracardiac lines, neurostimulators, medication infusion device, any other implants near the scalp (e.g., cochlear implants) or in the eye, metal in the body (e.g., splinters, fragments, clips)
• Pregnancy
• History of skull fractures, or skin diseases
• History of ongoing or unmanaged seizures
• Presence of factors that potentially decrease seizure thresholds: on pro-convulsant medications, untreated sleep deprivation or insomnia, ongoing alcoholism or illegal drug abuse (e.g., cocaine or MDMA users)
• History of dyslexia or other developmental learning disabilities

Sponsors & Collaborators

• Medical College of Wisconsin: lead

Study Sites (1)

Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States

RECRUITING

Related Publications (34)

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MeSH Terms

Conditions

Aphasia; Stroke; Language

Condition Hierarchy (Ancestors)

Speech Disorders; Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Communication; Behavior

Central Study Contacts

Sidney Schoenrock, MA

CONTACT

414-955-7579; sschoenrock@mcw.edu

Ari Hjelmeseth

CONTACT

414-955-7578; ahjelmeseth@mcw.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: February 17, 2025
• First Posted: May 15, 2025
• Study Start: September 1, 2025
• Primary Completion (Estimated): December 31, 2036
• Study Completion (Estimated): December 31, 2036
• Last Updated: September 19, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)