Low- vs. Normal-Flow Anesthesia and Delirium After Hip Fracture in the Elderly

NCT06973967 | Not Yet Recruiting DMC

• 1 other identifier: GaziosmanpasaTREH, VD
• Study Type: observational
• Target: 128
• Locations: 0 countries
• Sites: N/A

Brief Summary

The aim of this study is to investigate the relationship between low-flow and normal-flow anesthesia techniques and the development of postoperative delirium in elderly patients undergoing surgery for hip fracture.

Conditions

Delirium - Postoperative; Low Flow Anesthesia; Elderly Patients (>65 Years); Hip Surgery

Keywords

delirium; hip surgery; elderly patients; low-flow anesthesia

Outcome Measures

Primary Outcomes (1)

• The incidence of postoperative delirium is lower in patients receiving low-flow anesthesia compared to those receiving normal-flow anesthesia.

  7 days

Secondary Outcomes (3)

• 28-day mortality

  28 days

• Correlation Between NIRS Monitoring Values and Postoperative Delirium

  7 days

• Correlation Between BIS Values and Postoperative Delirium

  First 7 postoperative days

Study Arms (1)

Patients over the age of 65 who undergo hip fracture surgery under general anesthesia

Patients over the age of 65 who undergo hip fracture surgery under general anesthesia

Behavioral: delirium

Interventions

delirium BEHAVIORAL

Postoperatively, patients were monitored for delirium for seven days.

Patients over the age of 65 who undergo hip fracture surgery under general anesthesia

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Elderly Patients Undergoing Hip Fracture Surgery

You may qualify if:

• Patients aged 65 years and older who are scheduled to undergo surgical treatment for hip fracture, classified as ASA physical status I-IV, and who have signed the informed consent form will be included in the study.

You may not qualify if:

• Patients with complex fractures (multiple fractures, extremity, abdominal, pelvic or sacral trauma, head trauma, etc.), those with relative contraindications to general anesthesia (e.g., known difficult airway, malignant hyperthermia), patients requiring postoperative intubated intensive care follow-up, those with a history of dementia, sleep disorders, or psychosis, individuals with serious neurological diseases (e.g., Parkinson's disease, stroke sequelae), those with a history of opioid, alcohol, or substance use, patients with cerebrovascular disease, those who underwent surgery within the past 6 months, patients with hearing or vision impairment, bleeding disorders or those taking medications affecting coagulation, patients with hypoalbuminemia (\<3 g/dL), preoperative anemia with hematocrit \<30%, known allergy to anesthetic drugs, severe cardiopulmonary failure, immobility, malnutrition, or those who are unable to comply with the study protocol will be excluded from the study.

Sponsors & Collaborators

• Gaziosmanpasa Research and Education Hospital: lead

MeSH Terms

Conditions

Emergence Delirium; Delirium

Condition Hierarchy (Ancestors)

Confusion; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Neurocognitive Disorders; Mental Disorders

Central Study Contacts

Veysel Dinç

CONTACT

+90 545 745 3472; drvdinc@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assist. Prof.

Study Record Dates

• First Submitted: May 6, 2025
• First Posted: May 15, 2025
• Study Start: May 8, 2025
• Primary Completion: July 31, 2025
• Study Completion: August 7, 2025
• Last Updated: May 15, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share