Pericapsular Nerve Group (PENG) Block on Pain During Participant Positioning for Spinal Anesthesia in Hip Fracture Surgery

NCT06813755 | Completed DMC

• 1 other identifier: E-10840098-202.3.02-6997
• Study Type: observational
• Target: 62
• Locations: 1 country
• Sites: 1

Brief Summary

Hip fracture surgery is a common orthopedic procedure, especially in elderly patients. These fractures are quite common in adults over the age of 65, and the one-year mortality rate ranges from 12% to 37%. Recent studies have suggested that general anesthesia and spinal anesthesia are not superior to each other in patients undergoing hip fracture surgery. Untreated/poorly managed perioperative pain is directly linked to delirium, poor prognosis, and secondary chronic pain in hip fracture patients. Therefore, considering the associated mortality, morbidity, and early recovery, control of perioperative pain should be one of the highest priorities of the anesthesiologist, regardless of the anesthesia method used.

Conditions

Femur Fracture; Hip Surgery

Keywords

peng block; regional anesthesia; geriatric population

Outcome Measures

Primary Outcomes (1)

• Pain scores on the Numeric Rating Scale (NRS)

  Changes in Numeric Rating Scale (NRS) at rest and on movement will be recorded at intervals. NRS is a unidimensional measure of pain intensity in adults. The NRS is a segmented numeric version of the visual analog scale (VAS) in which a respondent selects a whole number (0-10 integers) that best reflects the intensity of his/her pain. The 11-point numeric scale ranges from '0' representing one pain extreme (e.g. "no pain") to '10' representing the other pain extreme (e.g. "pain as bad as you can imagine" or "worst pain imaginable").

  Group A: 5 minutes after intervention (intravenous opioid), Group B: 20 minutes after intervention (PENG block)

Secondary Outcomes (3)

• Duration of spinal anesthesia performance

  Group A: 5 minutes after intervention (intravenous ketamine), Group B: 20 minutes after intervention (PENG block)

• Quality of patient's position

  Group A: 5 minutes after intervention (intravenous ketamine), Group B: 20 minutes after intervention (PENG block)

• Analgesic consumption

  24 hours

Study Arms (2)

Procedure: PENG Block Pericapsular Nerve Group Block

Active Comparator: PENG Block For patients with hip fracture and having hip surgery this study evaluates the analgesic effects of Pericapsular Nerve Group (PENG) block for positioning before spinal anesthesia.

Drug: Conventional intravenous sedoanalgesia (ketamine) standardised intravenous sedoanalgesia agent

Active Comparator: Control in this group, standardised sedoanalgesia doses (drug: ketamine) will be used for analgesia for positioning pain

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

A total of 60 participants older than the age of 40 who will undergo hip fracture surgery under spinal anesthesia will be included in the study.

You may qualify if:

• hip fracture aged between 35 and 90 years old

You may not qualify if:

• contraindications for spinal anesthesia and PENG block impaired cognition or dementia multiple fractures any previous analgesic administration during the last 12 hours

Sponsors & Collaborators

• Marmara University: lead

Study Sites (1)

Istanbul Training and Research Hospital

Istanbul, Turkey (Türkiye)

Location

Related Publications (1)

• Aygun H, Tulgar S, Yigit Y, Tasdemir A, Kurt C, Genc C, Bilgin S, Senoglu N, Koksal E. Effect of ultrasound-guided pericapsular nerve group (PENG) block on pain during patient positioning for central nervous blockade in hip surgery: a randomized controlled trial. BMC Anesthesiol. 2023 Sep 15;23(1):316. doi: 10.1186/s12871-023-02245-3.

  PMID: 37715173 BACKGROUND

MeSH Terms

Conditions

Femoral Fractures

Condition Hierarchy (Ancestors)

Fractures, Bone; Wounds and Injuries; Leg Injuries

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: medical doctor

Study Record Dates

• First Submitted: December 9, 2024
• First Posted: February 7, 2025
• Study Start: November 20, 2024
• Primary Completion: May 20, 2025
• Study Completion: May 26, 2025
• Last Updated: May 29, 2025

Record last verified: 2025-05

Locations

TU (1)