NCT06973551

Brief Summary

This randomized controlled trial investigates the effects of a nostalgia-based cognitive training intervention delivered via Virtual Reality (VR) on emotional well-being and cognitive functioning among community-dwelling older adults (≥65 years) in northern Taiwan, specifically targeting those with mild cognitive impairment (MCI) or mild dementia. The study, conducted at National Taiwan Normal University, aims to assess whether engaging older adults in nostalgic VR experiences can enhance nostalgia proneness, life satisfaction, and psychological well-being, while also reducing depressive symptoms and improving cognitive functions. Participants who meet inclusion criteria (aged 65+, capable of communicating in Mandarin or Taiwanese, without severe psychiatric conditions, with sufficient vision/hearing) will be randomly assigned to either the experimental group receiving the "Brain Health Nostalgic VR Program" or a control group engaged in routine weekly activities. Each session, scheduled twice weekly, spans 25-35 minutes in total, including setup, support, and breaks, while the actual VR usage time is 15-25 minutes depending on individual tolerance. Research staff will provide close support and safety monitoring during all sessions. Pre- and post-intervention outcomes will be measured using standardized assessments: Southampton Nostalgia Scale (SNS), Short-Form Life Satisfaction Index (LSI-SF), Geriatric Depression Scale (GDS-15), Short-Form Chinese version of Ryff's Psychological Well-being Scale (PWB-18), and the Montreal Cognitive Assessment Taiwan Version (MoCA-T). The study emphasizes participant safety and data confidentiality throughout its duration. Findings aim to demonstrate VR's potential as a non-invasive, preventive strategy for cognitive decline and mental health enhancement among older populations.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
64

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Apr 2025

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 29, 2025

Completed
8 days until next milestone

First Submitted

Initial submission to the registry

May 7, 2025

Completed
8 days until next milestone

First Posted

Study publicly available on registry

May 15, 2025

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 10, 2026

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 30, 2026

Completed
Last Updated

April 21, 2026

Status Verified

April 1, 2026

Enrollment Period

10 months

First QC Date

May 7, 2025

Last Update Submit

April 15, 2026

Conditions

Keywords

Older adultsMild Cognitive ImpairmentDementiaCognitive Trainingnostalgia-based virtual realityAging and Cognitive HealthVirtual Reality Cognitive Training

Outcome Measures

Primary Outcomes (1)

  • Change in Cognitive Function Assessed by MoCA-T

    Cognitive function will be measured using the Montreal Cognitive Assessment - Taiwan Version (MoCA-T), a validated tool for detecting mild cognitive impairment (MCI) and early dementia. The MoCA-T assesses multiple domains including memory, attention, executive function, language, and visuospatial skills. Score range: 0-30 Interpretation: Higher scores indicate better cognitive functioning. For the Taiwanese version, a cutoff score of 23/24 has been suggested as the optimal threshold for distinguishing MCI patients from cognitively normal controls.

    Baseline, post-intervention (up to 8 weeks), and 3 months post-intervention

Secondary Outcomes (4)

  • Change in Nostalgia Proneness Assessed by Southampton Nostalgia Scale (SNS)

    Baseline, post-intervention (up to 8 weeks), and 3 months post-intervention

  • Change in Depression Symptoms Assessed by GDS-15

    Baseline, post-intervention (up to 8 weeks), and 3 months post-intervention

  • Change in Psychological Well-being Assessed by PWB-18

    Baseline, post-intervention (up to 8 weeks), and 3 months post-intervention

  • Change in Life Satisfaction Assessed by LSI-SF

    Baseline, post-intervention (up to 8 weeks), and 3 months post-intervention

Study Arms (2)

Nostalgia-Based VR Cognitive Training

EXPERIMENTAL

Participants in this arm will receive the "Brain Health Nostalgic VR Program," a culturally grounded virtual reality intervention integrating nostalgic elements representative of Taiwanese culture (e.g., old photographs, household objects, traditional media, and familiar scenarios) with interactive cognitive training. The training targets seven domains: attention, imagination and creativity, observation, memory, reasoning, reading comprehension, and thinking. Each session spans 25-35 minutes in total, including setup, support, brief reflection, and closure, while the actual VR usage time is 15-25 minutes depending on individual tolerance. The intervention is conducted in 12 sessions, scheduled in principle twice weekly, at the participant's day-care center, with full assistance and monitoring by the research team.

Behavioral: Brain Health Nostalgic VR Program

Routine Weekly Activities

NO INTERVENTION

Participants in this arm will continue with their routine weekly activities provided by their respective long-term care facilities. These activities may include light physical exercise, social engagement, passive entertainment (e.g., watching TV), or unstructured leisure. No structured cognitive training or VR-related content will be administered. This arm serves as a control group for comparison with the experimental group receiving the nostalgia-based VR intervention.

Interventions

The "Brain Health Nostalgic VR Program" is a culturally tailored virtual reality intervention integrating nostalgic content from Taiwanese culture (e.g., vintage photographs, familiar objects, historical TV clips, traditional settings) with interactive cognitive training tasks. The program targets seven cognitive domains: attention, imagination and creativity, observation, memory, reasoning, reading comprehension, and thinking. Each session spans 25-35 minutes, with 15-25 minutes of actual VR use based on participant tolerance, each participant will use VR for no more than 30 minutes per session before taking a break. Participants receive 12 sessions, scheduled in principle twice weekly. The intervention is delivered individually at the participant's day-care center, with researcher support provided throughout.

Also known as: nostalgia-based virtual reality, Elderly Brain Boosting Nostalgic VR, Nostalgia-Based VR Cognitive Training
Nostalgia-Based VR Cognitive Training

Eligibility Criteria

Age65 Years+
Sexall
Healthy VolunteersNo
Age GroupsOlder Adult (65+)

You may qualify if:

  • Age 65 years or older
  • Able to communicate in Mandarin or Taiwanese
  • Capable of wearing and operating a VR headset and handheld controllers
  • Sufficient vision and hearing to interact with VR content (assistive devices permitted)
  • Able to provide informed consent or have a legal guardian provide consent

You may not qualify if:

  • Diagnosis of severe dementia or advanced neurodegenerative disease
  • Severe psychiatric disorders (e.g., schizophrenia, bipolar disorder)
  • Major visual or auditory impairments that would interfere with VR use, even with assistive devices
  • Unconsciousness, inability to stay awake or focused for the session duration Inability to comply with study protocol or scheduled sessions

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

National Taiwan Normal University

Taipei, Taipei City, 10610, Taiwan

Location

MeSH Terms

Conditions

Cognitive DysfunctionDementiaPsychological Well-Being

Condition Hierarchy (Ancestors)

Cognition DisordersNeurocognitive DisordersMental DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesPersonal SatisfactionBehavior

Study Officials

  • Jong-Long Guo, PhD

    National Taiwan Normal University

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Model Details: This study adopts a parallel-group randomized controlled trial design. Eligible participants are randomly assigned to either an experimental group (receiving nostalgia-based VR cognitive training) or a control group (engaging in routine weekly activities without specific intervention). The intervention consists of 12 sessions over 6-8 weeks, with follow-up assessments conducted at 3 months post-intervention, enabling direct comparison of outcomes between groups.
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 7, 2025

First Posted

May 15, 2025

Study Start

April 29, 2025

Primary Completion

February 10, 2026

Study Completion

March 30, 2026

Last Updated

April 21, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will share

De-identified individual participant data (IPD) will be available after publication of the main trial results in an international peer-reviewed journal. Access requires a formal request to the corresponding author and approval. Shared data will include variables related to primary and secondary outcomes (e.g., demographics, cognitive function, well-being, depression, and life satisfaction). Data will be provided for academic, non-commercial research only, beginning 6 months after publication and up to 3 years thereafter. Qualified researchers must submit a sound proposal; upon approval, data will be securely transferred electronically.

Locations