Dietary Inflammatory Potential in Young Pleople With Obesity

NCT06971666 | Not Yet Recruiting DMC

• 1 other identifier: ITESO-DIP-2025
• Study Type: observational
• Target: 170
• Locations: 0 countries
• Sites: N/A

Brief Summary

The increase in adipose tissue in the young population is one of the most important and worrying public health problems because it persists in adulthood, constituting a risk factor for chronic degenerative diseases with social, economic, and environmental effects. The etiology of obesity is multifactorial and is associated with a low-intensity chronic inflammation process. Therefore, side effects of the digestive, nervous, endocrine, and immunological levels are closely related. Thus, understanding the impact of dietary components on the immune response and the pathophysiological complications of obesity will strengthen information on nutritional patterns with lower inflammatory implications.

Conditions

Obesity; Dietary Inflammatory Index (DII)

Keywords

obesity; dietary inflammatory potential; dietary inflammatory index; inflammatory markers; gut microbiota; anxiety; depression

Outcome Measures

Primary Outcomes (3)

• Dietary Assessment

  Dietary intake will be estimated from a validated semiquantitative food frequency questionnaire (FFQ) that represents food consumption for the last 12 months. For each item, regular portion size will be established, and then frequencies of consumption will be available, ranging from "never" to "6 or more times/day". Energy and nutrient intakes will be obtained by multiplying the frequency by the serving size from Mexican food composition.

  1.5 years

• Dietary Inflammatory Index, DII

  For the Dietary Inflammatory index, 45 food parameters related (positively or negatively) to inflammatory markers such as IL beta, IL4, IL6, IL10, TNF alpha, and CRP will be used. The score for each dietary parameter will be multiplied by each participant's intake, resulting in a numerical score ranging from -8 to +8.

  1.5 years

• Dietary Inflammatory Potential, DIP

  The DIP will be obtained by analyzing the Dietary assessment and the Dietary Inflammatory Index intake, which will then be converted to a percentile score of 2 and subtracted by 1. The percentile score will be multiplied by the inflammatory effect score. All food parameters sill be summed to create the score. The score will be in quartiles: Q1, highly anti-inflammatory, Q2, anti-inflammatory, Q3, inflammatory; and Q4, highly inflammatory

  1.5 years

Secondary Outcomes (12)

• Inflammatory markers

  1.5 years

• C-reactive protein (CRP)

  1.5 years

• Intestinal microbiota

  1.5 years

• Height

  1.5 years

• Body weight

  1.5 years

Study Arms (1)

Observational, cross-sectional, analytical, and correlational

An observational, cross-sectional, analytical, and correlational study will be conducted on young individuals with obesity, diagnosed with Body Mass Index (BMI). The study aims to analyze the correlation between Dietary inflammatory potential (DIP), inflammatory markers, intestinal dysbiosis, exercise patterns, and the risk of anxiety and depression

Eligibility Criteria

• Age: 18 Years - 24 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Individuals aged 18 to 24 years, diagnosed with obesity based on Body Mass Index (BMI), recruited from the Centro Universitario de Tonalá at the University of Guadalajara and ITESO between August 2024 and June 2025, residing in the Guadalajara Metropolitan Area.

You may qualify if:

• Age between 18 and 24 years
• Body Mass Index (BMI) ≥ 30 kg/m²
• Signed informed consent

You may not qualify if:

• Pregnancy or expected pregnancy within the next month
• Women who are breastfeeding
• Diagnosed conditions such as: diabetes mellitus, hypertension, renal or hepatic insufficiency, infectious diseases, inflammatory diseases, or any neoplastic disease
• Conditions with dietary restrictions, such as celiac disease or history of gastric bypass surgery
• Active alcoholism with a daily intake exceeding 50 g/day
• Significant anticipated changes in diet or exercise within 15 days prior to the study's start
• History of drug or medication abuse
• Eating disorders
• Participation in any study involving investigational products within the 3 months prior to the start of the study
• Treatment with anti-inflammatory drugs, antibiotics, and/or antidepressants in the month prior to the study's start
• Consumption of nutraceuticals containing prebiotics, probiotics, or immunomodulators within 15 days prior to the study's start
• Individuals who choose to discontinue participation after the data collection process has started.
• Individuals who do not consent to the collection of any of the required samples (blood, diet, or stool) during the data collection phase.

Sponsors & Collaborators

• Instituto Tecnológico y de Estudios Superiores de Occidente: lead

Related Publications (8)

• Baltazar-Diaz TA, Gonzalez-Hernandez LA, Aldana-Ledesma JM, Pena-Rodriguez M, Vega-Magana AN, Zepeda-Morales ASM, Lopez-Roa RI, Del Toro-Arreola S, Martinez-Lopez E, Salazar-Montes AM, Bueno-Topete MR. Escherichia/Shigella, SCFAs, and Metabolic Pathways-The Triad That Orchestrates Intestinal Dysbiosis in Patients with Decompensated Alcoholic Cirrhosis from Western Mexico. Microorganisms. 2022 Jun 16;10(6):1231. doi: 10.3390/microorganisms10061231.

  PMID: 35744749 BACKGROUND

• Hadi S, Momenan M, Cheraghpour K, Hafizi N, Pourjavidi N, Malekahmadi M, Foroughi M, Alipour M. Abdominal volume index: a predictive measure in relationship between depression/anxiety and obesity. Afr Health Sci. 2020 Mar;20(1):257-265. doi: 10.4314/ahs.v20i1.31.

  PMID: 33402914 BACKGROUND

• Craig CL, Marshall AL, Sjostrom M, Bauman AE, Booth ML, Ainsworth BE, Pratt M, Ekelund U, Yngve A, Sallis JF, Oja P. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003 Aug;35(8):1381-95. doi: 10.1249/01.MSS.0000078924.61453.FB.

  PMID: 12900694 BACKGROUND

• Corley J, Shivappa N, Hebert JR, Starr JM, Deary IJ. Associations between Dietary Inflammatory Index Scores and Inflammatory Biomarkers among Older Adults in the Lothian Birth Cohort 1936 Study. J Nutr Health Aging. 2019;23(7):628-636. doi: 10.1007/s12603-019-1221-y.

  PMID: 31367727 BACKGROUND

• Cavicchia PP, Steck SE, Hurley TG, Hussey JR, Ma Y, Ockene IS, Hebert JR. A new dietary inflammatory index predicts interval changes in serum high-sensitivity C-reactive protein. J Nutr. 2009 Dec;139(12):2365-72. doi: 10.3945/jn.109.114025. Epub 2009 Oct 28.

  PMID: 19864399 BACKGROUND

• Boutens L, Hooiveld GJ, Dhingra S, Cramer RA, Netea MG, Stienstra R. Unique metabolic activation of adipose tissue macrophages in obesity promotes inflammatory responses. Diabetologia. 2018 Apr;61(4):942-953. doi: 10.1007/s00125-017-4526-6. Epub 2018 Jan 14.

  PMID: 29333574 BACKGROUND

• Amiri S, Behnezhad S. Obesity and anxiety symptoms: a systematic review and meta-analysis. Neuropsychiatr. 2019 Jun;33(2):72-89. doi: 10.1007/s40211-019-0302-9. Epub 2019 Feb 18.

  PMID: 30778841 BACKGROUND

• Almeida-de-Souza J, Santos R, Barros R, Abreu S, Moreira C, Lopes L, Mota J, Moreira P. Dietary inflammatory index and inflammatory biomarkers in adolescents from LabMed physical activity study. Eur J Clin Nutr. 2018 May;72(5):710-719. doi: 10.1038/s41430-017-0013-x. Epub 2017 Dec 26.

  PMID: 29277838 BACKGROUND

MeSH Terms

Conditions

Obesity; Anxiety Disorders; Depression

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Mental Disorders; Behavioral Symptoms; Behavior

Central Study Contacts

Karla Janetté Nuño, PhD

CONTACT

+52 33 3669 34; karlanuno@iteso.mx

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 20, 2025
• First Posted: May 14, 2025
• Study Start: June 20, 2025
• Primary Completion (Estimated): November 22, 2026
• Study Completion (Estimated): January 7, 2027
• Last Updated: May 14, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share