NCT06967220|Enrolling By Invitation
The Impact of Inflammation on Skeletal Muscle Maintenance in Hospitalized Patients
InflaMus
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InflaMus
Sponsor study identifier
interventional
90
1 country
1
Study Start
May 12, 2025
Actual (reported)Primary Completion
April 22, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
April 22, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
The main goal is to elucidate the mechanistic coupling between inflammation and the ability to maintain skeletal muscle through physical exercise while hospitalized. We will investigate protein kinetics in patients who belong to one of three groups 1) high inflammatory state, 2) moderate inflammatory state and 3) low/no inflammation. We will further intervene in group 1 (high inflammatory state) with anti-inflammatory nutrition (primarily green-solution plant-based) to diminish activity in inflammatory pathways. The hypothesis is that inflammation will inhibit protein synthesis in skeletal muscle both in resting muscle and in strength trained skeletal musculature, and that a lowering of the inflammatory status by anti-inflammatory nutrition will enhance the exercise induced formation of new muscle mass. .
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 22, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 17, 2025
Actual (reported)May 12, 2025
Actual (reported)May 13, 2025
Actual (reported)April 22, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
April 22, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
FSR in high vs. low inflammation group
The primary outcome is the muscle protein fractional synthesis rate (FSR) in the high inflammation group vs. the low inflammation group
7 days (or until hospital discharge)
Change in muscle size between groups
7 days (or until hospital discharge)
FSR in trained vs. non trained leg
7 days (or until hospital discharge)
Inflammation in regular vs. antiinflammatory diet
7 days (or until hospital discharge)
AA uptake following feeding
7 days (or until hospital discharge)
Muscle size in trained vs. untrained leg
7 days (or until hospital discharge)
Feasibility of training
7 days (or until hospital discharge)
A sub group of patients with high inflammation will be offered a diet where 50% of the regular hospital diet is switched for diet containing plant based food and nutrients found to lower inflammation
All subjects will train one leg twice daily.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Bispebjerg Hospital
Copenhagen, 2400, Denmark
First Submitted
April 17, 2025
First Posted
May 13, 2025
Study Start
May 12, 2025
Actual (reported)Primary Completion
April 22, 2026
Estimated (date passed)Tolerance, Palatability and Acceptability Evaluation of an Oral Nutrition Supplement
Contact the study team to confirm eligibility.
This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
April 22, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
May 15, 2025
Record last verified: 2025-04
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Source: ClinicalTrials.gov.
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