Combining Electrical Impedance Tomography and Thoracic Ultrasound Toinvestigate Dynamic Changes

NCT06958770 | Not Yet Recruiting

• 1 other identifier: 202502091RIND
• Study Type: observational
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

1. 1.To evaluate the dynamic changes of lung ultrasound during electrical impedance tomography (EIT) PEEP titration and across the first week of ARDS.
2. 2.To asses respiratory effort by diaphragmatic function, esophageal pressure, and EIT (Pendelluft phenomenon), and hyperinflammatory biomarkers, to predict P-SILI.
3. 3.To develop predictive models for weaning success based on integrated EELI and thoracic ultrasound.

Conditions

ARDS (Moderate or Severe)

Keywords

Chest ultrasound; electrical impedance tomography

Outcome Measures

Primary Outcomes (1)

• ARDS

  Correlation of LUS aeration scores and overdistension metrics (e.g., A-line prominence, reduced lung sliding) with EIT parameters, including hyperdistension (%), collapse (%), and ΔEELI. Correlation of P-SILI risk with diaphragmatic function (ultrasound-measured excursion and thickening fraction), esophageal pressure variations (ΔPes, ΔPdi), pendelluft dynamics (phase shift, amplitude difference from EIT), and hyperinflammatory biomarkers (e.g., IL-6, IL-8).

  From enrollment to the end of treatment at 1 weeks.

Interventions

Electrical impedance tomography DIAGNOSTIC_TEST

* Electrical impedance tomography (EIT)：Assessing pulmonary function in chronic lung diseases. * Lung ultrasound：Assessing diaphragm atrophy in mechanically ventilated patients. * Esophageal pressure：The work of breathing, or the energy required by respiratory muscles to meet ventilatory demands, can be directly evaluated by esophageal pressure * Oxygen consumption：Indirectly evaluated by measuring oxygen consumption (V̇O2) during mechanical ventilation The oxygen cost of breathing, reflected the increase in V̇O2 when transitioning from mechanical ventilation to spontaneous breathing, has been shown to predict weaning outcomes.

Also known as: Lung ultrasound, Esophageal pressure, Oxygen consumption

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Admitted into ICU, diagnosed as moderate or severe ARDS (ICD-10-CM: J80) according to Berlin definition.

You may qualify if:

• Adult \>18 y/o.
• Patient intubated and receiving mechanical ventilation \> 24 hours.
• Admitted into ICU, diagnosed as moderate or severe ARDS (ICD-10-CM: J80) according to Berlin definition.

You may not qualify if:

• Presence of Implanted Electronic Devices (pacemakers, implantable cardioverter-defibrillators).
• Pregnancy.
• No consent/inability to obtain consent and appropriate legal representative not available.

Sponsors & Collaborators

• National Taiwan University Hospital: lead

MeSH Terms

Conditions

Lymphoma, Follicular

Interventions

Oxygen Consumption

Condition Hierarchy (Ancestors)

Lymphoma, Non-Hodgkin; Lymphoma; Neoplasms by Histologic Type; Neoplasms; Lymphoproliferative Disorders; Lymphatic Diseases; Hemic and Lymphatic Diseases; Immunoproliferative Disorders; Immune System Diseases

Intervention Hierarchy (Ancestors)

Metabolism

Study Officials

• Yao-Wen Kuo

  National Taiwan University Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Yao-Wen Kuo

CONTACT

886+972651821; kyw@ntu.edu.tw

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 27, 2025
• First Posted: May 6, 2025
• Study Start: May 19, 2025
• Primary Completion (Estimated): December 31, 2028
• Study Completion (Estimated): December 31, 2028
• Last Updated: May 6, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share