Effect of Fresh Gas Flow Differences on Postoperative Nausea and Vomiting

NCT06952946 | Completed

• 1 other identifier: AURH-AR-UK-01
• Study Type: interventional
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to investigate the effect of fresh gas flow applied during general anesthesia on the incidence of postoperative nausea and vomiting in patients undergoing septorhinoplasty surgery. Patients who agree to participate in the study will be divided into three groups according to the fresh gas flow applied: low flow (0.5 lt/min) (Group L), medium flow (2 lt/min) (Group M) and high flow (4 lt/min) (Group H), and the postoperative nausea and vomiting data of the groups will be compared.

Conditions

Nausea and Vomiting, Postoperative; Septoplasty/Septorhinoplasty

Keywords

fresh gas flow; low flow anesthesia; postoperative nausea vomiting

Outcome Measures

Primary Outcomes (1)

• postoperative nausea and vomiting

  The patients' postoperative nausea and vomiting scores will be assessed when they are taken to the postoperative care room, immediately before being transferred from the postoperative care room to the ward (at the 30th minute postoperatively), at the 1st hour postoperatively, at the 6th hour postoperatively, at the 12th hour postoperatively, and at the 24th hour postoperatively. Nausea will be assessed by scoring with a numerical rating scale between 0 and 10. Vomiting will be questioned. If vomiting occurs, the number of times it occurs will be questioned. Whether postoperative antiemetics are used and if so, how many mg are used will be recorded. If postoperative opioids are used, how many mg are used will be recorded.

  24 hours

Secondary Outcomes (3)

• intraoperative body temperature

  intraoperative

• Whether kidney functions are affected

  1 hour postoperative

• whether liver functions are affected

  1 hour postoperative

Study Arms (3)

low flow anesthesia group

ACTIVE COMPARATOR

After endotracheal intubation, fresh gas flow will be applied at 4 lt/min for 8 minutes, and in the low-flow anesthesia group, it will be reduced to 0.5 lt/min and maintained at this flow throughout the surgery.

Other: 0.5 lt/dk fresh gas flow

medium flow anesthesia group

ACTIVE COMPARATOR

After endotracheal intubation, fresh gas flow will be applied at 4 lt/min for 8 minutes, and in the medium-flow anesthesia group, it will be reduced to 2 lt/min and maintained at this flow throughout the surgery.

Other: 2 lt/dk fresh gas flow

high flow anesthesia group

ACTIVE COMPARATOR

After endotracheal intubation, fresh gas flow will be applied at 4 lt/min for 8 minutes and then continued in the same manner (4 lt/min) in the high-flow anesthesia group.

Other: 4 lt/dk fresh gas flow

Interventions

0.5 lt/dk fresh gas flow OTHER

Fresh gas flow will be set to 0.5 l/min in the low flow anesthesia group.

low flow anesthesia group

2 lt/dk fresh gas flow OTHER

Fresh gas flow will be set to 2 lt/min in the medium flow anesthesia group.

medium flow anesthesia group

4 lt/dk fresh gas flow OTHER

Fresh gas flow will be set to 4 lt/min in the high flow anesthesia group.

high flow anesthesia group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients who agreed to participate in the study
• years of age
• ASA I-II risk group patients

You may not qualify if:

• Patient does not accept the study
• Presence of psychiatric disorder and patient's inability to cooperate
• Cognitive dysfunction
• Hearing problems
• History of alcohol or drug addiction
• Presence of a serious pre-existing medical condition that limits objective assessment
• Complications developed during surgery
• Presence of any life-threatening condition after surgery
• Patient's classification is ASA III-IV

Sponsors & Collaborators

• Adiyaman University Research Hospital: lead

Study Sites (1)

Adıyaman Training and Research Hospital

Adıyaman, Merkez, 02040, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Postoperative Nausea and Vomiting

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Nausea; Signs and Symptoms, Digestive; Signs and Symptoms; Vomiting

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Researchers who will evaluate postoperative nausea and vomiting and patients participating in the study will be blinded to the difference in fresh gas flow that will be applied to them.
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Specialist physician

Model Details: Three groups to which fresh gas flow is applied as low flow (0.5 l/min), medium flow (2 l/min) and high flow (4 l/min).

Study Record Dates

• First Submitted: April 14, 2025
• First Posted: May 1, 2025
• Study Start: March 10, 2025
• Primary Completion: September 28, 2025
• Study Completion: September 30, 2025
• Last Updated: January 14, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)