Evaluation Of The Effect Of SGLT-2 Inhibitors On Atrial Fibrillation Recurrence In Diabetic Patients

NCT06951737 | Completed

• 1 other identifier: Bursa SUAM
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

Consecutive DCCV was performed until to achieve 120 patients in SR (60 DM patients who used SGLT-2 inhibitors and 60 DM patients who did not use SGLT-2 inhibitors). Patients defined as SGLT-2 inhibitor user group and control group. The two groups were monitored for AF recurrence on the first day, then at one, three, and six months after CV.

Conditions

Diabetes Mellitus; Atrial Fibrillation (AF)

Outcome Measures

Primary Outcomes (1)

• Atrial fibrillation recurrence

  six month

Study Arms (1)

SGLT-2 inhibitor user

patients with diabetes mellitus, atrial fibrillation and using SGLT-2 inhibitor

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients diagnosed with DM and AF who were planned to undergo electrical cardioversion were evaluated for suitability for the study.

You may qualify if:

• patients \> 18 years and \< 90 years,
• Patient diagnosed with DM
• Patient underwent electrical cardioversion due to AF and was restored to sinus rhythm

You may not qualify if:

• patient who are not suitable for anticoagulant use,
• have thyroid dysfunction,
• glomerular filtration rate ≤ 25 ml/min/1.73 m²,
• patients whose sinus rhythm cannot be achieved with electrical cardioversion,
• malignancy patients,
• patients with acute or chronic inflammatory disease,
• patients with peripheral artery disease,
• patients with pacemakers,
• patients with advanced valve stenosis or insufficiency,
• patients who have had coronary bypass surgery,
• patients with percutaneous or surgical bioprosthesis or metallic valve surgery.

Sponsors & Collaborators

• Bursa Postgraduate Hospital: lead

Study Sites (1)

Bursa Yüksek İhtisas Hastanesi

Bursa, Turkey (Türkiye)

Location

Related Publications (1)

• Yarar M, Ari H, Ari S, Tutuncu A, Melek M, Bozat T. Evaluation of the effect of SGLT-2 inhibitors on atrial fibrillation recurrence in diabetic patients. Expert Opin Pharmacother. 2025 Aug;26(11-12):1343-1349. doi: 10.1080/14656566.2025.2527189. Epub 2025 Jul 3.

  PMID: 40579747 DERIVED

MeSH Terms

Conditions

Diabetes Mellitus; Atrial Fibrillation

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Arrhythmias, Cardiac; Heart Diseases; Cardiovascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof Dr

Study Record Dates

• First Submitted: April 20, 2025
• First Posted: April 30, 2025
• Study Start: October 2, 2022
• Primary Completion: April 2, 2024
• Study Completion: October 2, 2024
• Last Updated: June 3, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)