Characteristics of Postinfectious Cough

NCT06951321 | Completed

• 1 other identifier: ES-2023-032-01
• Study Type: observational
• Target: 1,650
• Locations: 1 country
• Sites: 1

Brief Summary

Collect the age, sex and other demographic data of 1600 patients with chronic cough after COVID-19 infection and clinical parameters such as cough characteristics, establish a cohort of patients with chronic cough after COVID-19 infection, observe the type and level of airway inflammation, airway responsiveness, cough sensitivity and changes in microbiology of patients with chronic cough after COVID-19 infection, clarify the epidemiological characteristics, clinical pathophysiological characteristics, long-term prognosis and related factors of patients with chronic cough after COVID-19 infection, explore the clinical pathophysiological characteristics and pathogenesis of cough after COVID-19 infection, and provide a theoretical basis for the treatment of persistent cough after COVID-19 infection.

Conditions

Cough

Keywords

cough

Outcome Measures

Primary Outcomes (1)

• cough duration

  The total cough duration after COVID-19 infection reported by the patient

  From enrollment to 1 year after the enrollment

Study Arms (1)

patients

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Cough lasts for more than 3 weeks after COVID-19 infection and there is still cough at the time of investigation

You may qualify if:

• Age between 18-70 years old, gender not limited;
• After COVID-19 infection (COVID-19 nucleic acid test or antigen test is positive, or there is a highly suspected symptom of COVID-19 infection), the cough lasts for more than 3 weeks and there is still cough at the time of investigation;
• No obvious abnormalities were found in chest imaging.

You may not qualify if:

• Combined with other respiratory infectious diseases (pneumonia, tuberculosis, etc.);
• Combined chronic respiratory diseases (asthma, chronic obstructive pulmonary disease, bronchiectasis, interstitial lung disease, etc.);
• Cough and expectoration were found 2 months before COVID-19 infection;
• Merge other serious organ diseases and malignant tumors;
• Pregnant and lactating women.

Sponsors & Collaborators

• Kefang Lai: lead

Study Sites (1)

The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, 510120, China

Location

Biospecimen

Retention: SAMPLES WITH DNA

Serum samples (200 cases), sputum supernatant (200 cases), original sputum (200 cases)

MeSH Terms

Conditions

Cough

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: professor

Study Record Dates

• First Submitted: April 14, 2025
• First Posted: April 30, 2025
• Study Start: March 1, 2023
• Primary Completion: April 1, 2025
• Study Completion: April 1, 2025
• Last Updated: April 30, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)