AccuIMR Predicts Microvascular Obstruction and Infarct Size in STEMI Patients

NCT06947564 | Completed DMC

• 1 other identifier: Early MYO IMR-CMR
• Study Type: observational
• Target: 843
• Locations: 1 country
• Sites: 1

Brief Summary

In this study, we aimed to investigate the clinical significance of the angiography-based IMR calculation method (AccuIMR) and its prognostic assessment capability by evaluating the concordance or discordance between AccuIMR values and cardiac magnetic resonance (CMR) results.

Conditions

Coronary Artery Disease; STEMI - ST Elevation Myocardial Infarction; Microvascular Coronary Artery Disease

Keywords

AccuIMR, CMR, infarct size

Outcome Measures

Primary Outcomes (1)

• CMR

  Contrast-enhanced CMR was performed on a 3.0-T scanner (Achieva TX, Philips Healthcare, Best, The Netherlands) . All sequences were acquired during breath-hold with a field of view at 350 × 350 mm2. Two experienced readers, blinded to clinical data, evaluated the CMR results using validated software (QMass MR 7.5, Medis, Leiden, The Netherlands). The acquired images were utilized to assess ventricular parameters and calculate the left ventricular ejection fraction (LVEF).

  CMR was performed at a median of 5 days post-reperfusion.

Secondary Outcomes (2)

• LDL-C, mmol/L

  Blood samples were collected after a 12-hour fast in the second day post-PCI.

• HbA1c, %

  Blood samples were collected after a 12-hour fast in the second day post-PCI.

Study Arms (1)

STEMI patients underwent CMR

STEMI patients who underwent PCI within 12 hours of symptom onset.

Diagnostic Test: CMR

Interventions

CMR DIAGNOSTIC_TEST

Coronary microvascular function was assessed using contrast-enhanced CMR after PCI.

STEMI patients underwent CMR

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

STEMI patients who underwent PCI within 12 hours of symptom onset, and coronary microvascular function was assessed using contrast-enhanced CMR after PCI.

You may qualify if:

• (1) STEMI patients who underwent PCI within 12 hours of symptom onset.
• (2) coronary microvascular function was assessed using contrast-enhanced CMR after PCI.

You may not qualify if:

• (1) Suboptimal coronary angiographic images, including inadequate contrast opacification, unsatisfactory projection view, and severe overlap or distortion of the target vessel.
• (2) Lacking two angiographic projections separated by at least 25° apart post-PCI.
• (3) Inadequate CMR image quality

Sponsors & Collaborators

• RenJi Hospital: lead

Study Sites (1)

Renji Hospital

Shanghai, Shanghai Municipality, 200127, China

Location

Related Publications (13)

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MeSH Terms

Conditions

Coronary Artery Disease; ST Elevation Myocardial Infarction

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Myocardial Infarction; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Officials

• Jun Pu, MD, PhD

  RenJi Hospital

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 20, 2025
• First Posted: April 27, 2025
• Study Start: January 1, 2012
• Primary Completion: December 31, 2023
• Study Completion: December 31, 2024
• Last Updated: April 27, 2025

Record last verified: 2025-04

Locations

CN (1)