NCT06945185

Brief Summary

Stroke is a leading cause of upper extremity deficits worldwide. Persistent upper extremity dysfunction affects many post stroke patients and is strongly associated with decreased activities of daily living and poor quality of life. There is accumulating evidence of a cross-over effect with training of one limb that slightly increase strength and coordination in contralateral untrained limb through neurological adaptations. One of rehabilitation that is beneficial for stroke patient is motor imagery, a mental rehearsal of a movement that does not include physical movement has been shown to enhance upper limb function. Evidence demonstrate that MI not only activates motor cortical and subcortical regions but also induces plastic change in motor networks and modulates synaptic activity at spinal level.

Trial Health

57
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Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
26

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Sep 2024

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 10, 2024

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

April 18, 2025

Completed
7 days until next milestone

First Posted

Study publicly available on registry

April 25, 2025

Completed
20 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 15, 2025

Completed
15 days until next milestone

Study Completion

Last participant's last visit for all outcomes

May 30, 2025

Completed
Last Updated

April 25, 2025

Status Verified

April 1, 2025

Enrollment Period

8 months

First QC Date

April 18, 2025

Last Update Submit

April 24, 2025

Conditions

Keywords

Motor ImageryStrokeNeurorehabilitationFunctional strength

Outcome Measures

Primary Outcomes (2)

  • FUNCTIONAL STRENGTH

    FUNCTONAL STRENGTH WILL BE ASSESSED USING WOLF MOTOR FUNCTION TEST

    8 weeks

  • Coordination

    The Action Research Arm Test (ARAT) will be used to assess upper extremity performance

    8 weeks

Study Arms (2)

CONTROL GROUP A- CONVENTIONAL PHYSICAL THERAPY

ACTIVE COMPARATOR

The participants will receive conventional physical therapy focusing on active range of motion, strengthing and coordination exercises. Subjects will receive protocol of 45 min thrice a week for 8 weeks with 2 min rest in between. The exercises will focus on active range of motion, weight exercises to increase strength and coordination exercises to improve movement coordination.

Procedure: Intervention Group A Conventional Physical Therapy

INTERVENTION GROUP B- MOTOR IMAGERY WITH CONVENTIONAL PHYSICAL

EXPERIMENTAL

The participants will recieve conventional physical therapy focusing on active range of motion, strengthing and coordination exercises. Subjects will recieve protocal of 45 min thrice a week for 8 weeks with 2 min rest in between. The exercises will focus on active range of motion, weight exercises to increase strength and coordination exercises to improve movement coordination.

Procedure: Intervention Group B Motor Imagery with Conventional Physical Therapy

Interventions

Active Range of Motion Exercises: (5-10 reps with 2 sets) Finger bends, finger spreads, finger to thumb opposition, thumb to palm stretches, palm up and down, wrist rotation, wrist bends, elbow bends, shoulder shrugging and shoulder rotation. Strengthening Exercises: (10-15 reps 2 sets weight 500 ml to 1L water bottle). Finger pinch, power grip, finger spread, pushing movement, wrist curls, roll and squeeze, bicep curls, side arm raise, lifting objects to a height, pulling resistance band. Coordination Exercises: (10-15 reps 2 sets) finger to finger, finger to doctor's finger, finger to nose, holding and lifting coins, buttoning, holding and lifting coins, alternate hand movement, closing and opening hand.

CONTROL GROUP A- CONVENTIONAL PHYSICAL THERAPY

1. Subjects will be asked to sit comfortably on a chair with a backrest. A Quiet environment is ensured for proper concentration of subject .Take deep breaths for 2-3 min to relax. 2. Subjects will be asked to close their eyes and imagine the training scene for each task for 5 min while listening to the therapist 's voice describing the motion. 3. The non-paralysis part of the body's movement was imagined first and then the movement of the paralysis part was imagined. 4. Upon completion of the mental practice for the first activity, the subject will be given a comfortable break. Motor Imagery Training: Week 1-2: Approaching and holding a cup, turning book pages and grasping pencil to write. Week 3-4: wiping desk, turning door handle and drinking water from cup. Week 5-6: pressing light switch on and off, turning faucet and putting card in wallet. Week 7-8: folding towel, brushing teeth and brushing hair. Imagine for 30 sec 2-3 repetitions.

INTERVENTION GROUP B- MOTOR IMAGERY WITH CONVENTIONAL PHYSICAL

Eligibility Criteria

Age45 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Stroke duration 6 months onwards (chronic stroke).
  • age 45 years and above.
  • Both genders.
  • Access cognitive function score \> 24 on MoCA.

You may not qualify if:

  • Patients with any comorbidity, previous surgery and congenital anomly.
  • Patient with any fracture/ MSK disorders.
  • Score 3 or more on Modified Ashworth scale.
  • Patients with hearing impairments

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Foundation University College of Physical Thrapy

Islamabad, 44000, Pakistan

RECRUITING

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular Diseases

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 18, 2025

First Posted

April 25, 2025

Study Start

September 10, 2024

Primary Completion

May 15, 2025

Study Completion

May 30, 2025

Last Updated

April 25, 2025

Record last verified: 2025-04

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