The Study of Differences in Eosinophil Function and Subsets in Patients With Eosinophilic Pulmonary Diseases

NCT06944418 | Recruiting DMC

• 1 other identifier: PUMCH-EPD
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

The study subjects of this research are patients with eosinophil-associated pulmonary diseases, including eosinophilic granulomatosis with polyangiitis, idiopathic hypereosinophilic syndrome, idiopathic acute eosinophilic pneumonia, idiopathic chronic eosinophilic pneumonia, and primary simple pulmonary eosinophilia. The aim is to detect eosinophil subtypes in peripheral blood based on surface protein expression, to understand the differences in eosinophil subtypes among patients with different diseases, to elucidate the significance of different eosinophil subtypes, and ultimately to provide a theoretical basis for the selection of treatment directions for patients.

Conditions

Eosinophil Subtype; Eosinophilic Pulmonary Diseases

Outcome Measures

Primary Outcomes (1)

• Proportion of Eosinophil Subtypes in Serum

  Proportion of Eosinophil Subtypes in Serum Before and After Treatment in Patients

  From January 1, 2024 to January 1, 2027

Interventions

observation OTHER

observation

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Outpatients diagnosed with EPD who meet the inclusion criteria above.

You may qualify if:

• For Healthy Volunteers: healthy volunteers matching the age and gender of the study subjects
• For EPD: ① Persistent eosinophil count increase\>1500 per cubic millimeter for more than 6 months. ② Lack of evidence of a secondary cause of eosinophilia is required. ③ Signs and symptoms of end-organ damage presumed to be secondary to eosinophilia

You may not qualify if:

• Patients with concurrent definitive pulmonary infections, malignancies, or other parenchymal lung diseases;
• Patients who are unable or unwilling to cooperate with the collection of clinical information (e.g., due to mental disorders, memory impairments, etc.);
• Patients who are unable to provide informed consent.

Sponsors & Collaborators

• Peking Union Medical College Hospital: lead

Study Sites (1)

Peking Union Medical College Hospital

Beijing, Beijing Municipality, 100730, China

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

serum

MeSH Terms

Interventions

Observation

Intervention Hierarchy (Ancestors)

Methods; Investigative Techniques

Study Officials

• Juhong Shi, M.D

  Peking Union Medical College Hospital

  STUDY CHAIR

Central Study Contacts

Juhong Shi, M.D

CONTACT

+8613701178492; shijh@pumch.cn

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 30, 2025
• First Posted: April 25, 2025
• Study Start: January 1, 2024
• Primary Completion: January 1, 2026
• Study Completion (Estimated): January 1, 2027
• Last Updated: April 25, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)