Impact of Traumatic Brain Injury on Hemodynamic Instability in Patients With Blunt Bowel and Mesenteric Injuries

NCT06942091 | Completed

• 1 other identifier: 201902275B0
• Study Type: observational
• Target: 169
• Locations: 0 countries
• Sites: N/A

Brief Summary

This retrospective cohort study aims to evaluate the impact of traumatic brain injury (TBI) on hemodynamic status in trauma patients with surgically confirmed blunt bowel and mesenteric injuries (BBMI). A total of 169 adult patients treated at a Level I trauma center between 2009 and 2023 were analyzed and stratified based on the presence or absence of concomitant TBI. Clinical parameters such as shock, massive transfusion, transfusion requirements, morbidity, and mortality were compared. The study investigates whether TBI is an independent risk factor for acute hemodynamic instability in BBMI patients, with the goal of improving trauma care strategies and understanding the systemic effects of TBI, particularly through the lens of the brain-gut axis.

Conditions

Traumatic Brain Injury; Blunt Abdominal Trauma; Hemodynamic Instability; Shock; Massive Transfusion

Outcome Measures

Primary Outcomes (2)

• Presence of Shock

  Proportion of BBMI patients who experienced shock, defined as systolic blood pressure \< 90 mmHg at the emergency department.

  At Emergency Department (initial presentation)

• Need for Massive Transfusion

  Proportion of BBMI patients who received more than 10 units of packed red blood cells within 24 hours after arrival.

  Within 24 hours of hospital admission

Secondary Outcomes (4)

• Amount of Transfusion Administered

  Within 24 hours of hospital admission

• In-hospital Morbidity

  Through hospital discharge, a median length of 17 days

• In-hospital Mortality

  Up to hospital discharge, a median length of 17 days

• ICU Length of Stay

  Through ICU stay during index hospitalization, a median length of 3 days

Study Arms (1)

TBI Group/non-TBI Group

TBI Group: Patients with blunt bowel and mesenteric injury (BBMI) with concomitant traumatic brain injury (TBI) Non-TBI Group: Patients with blunt bowel and mesenteric injury (BBMI) without TBI

Other: Traumatic Brain Injury (TBI)

Interventions

Traumatic Brain Injury (TBI) OTHER

Presence of TBI identified by intracerebral hemorrhage on brain computed tomography (CT) at emergency department; not actively assigned by investigators but used to stratify comparison groups.

TBI Group/non-TBI Group

Eligibility Criteria

• Age: 16 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult trauma patients underwent surgically confirmed blunt bowel and mesenteric injuries.

You may qualify if:

• Adults aged \>16 years
• Patients with surgically confirmed blunt bowel and/or mesenteric injuries (BBMI)
• Underwent therapeutic laparotomy
• Complete emergency department and operative records available

You may not qualify if:

• Isolated gastric, duodenal, or rectal injuries
• Pediatric patients (\<16 years)
• Incomplete or missing clinical records
• Penetrating trauma
• Patients who did not undergo surgery

Sponsors & Collaborators

• Chang Gung Memorial Hospital: lead

MeSH Terms

Conditions

Brain Injuries, Traumatic; Shock

Condition Hierarchy (Ancestors)

Brain Injuries; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Attending Physician

Study Record Dates

• First Submitted: April 13, 2025
• First Posted: April 24, 2025
• Study Start: January 1, 2009
• Primary Completion: December 31, 2023
• Study Completion: December 31, 2023
• Last Updated: April 24, 2025

Record last verified: 2025-04