Marathon Runners With Type 1 Diabetes

NCT06935903 | Completed

• 2 other identifiers: NdS/544750/2021/20221245/18
• Study Type: observational
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to learn about the physical capacity and metabolic characteristics of male marathon runners with type 1 diabetes mellitus (T1DM). The main question it aims to answer is: Do male marathon runners with T1DM have different physical fitness and metabolic profiles compared to healthy runners without diabetes? Participants with T1DM and healthy controls who have completed a marathon will undergo a single in-person assessment, including body composition analysis, resting metabolic rate measurement, and a maximal exercise test

Conditions

Type 1 Diabetes (T1D)

Keywords

Type 1 Diabetes; Physical Activity; Physical Endurance; Absorptiometry; Oxygen Consumption

Outcome Measures

Primary Outcomes (1)

• VO₂max (mL/kg/min)

  peak oxygen uptake during graded exercise testing

  single visit

Secondary Outcomes (6)

• Resting metabolic rate (kcal/day)

  single visit

• Body adipose percentage [%]

  single visit

• Lean tissue percentage [%]

  single visit

• Forced Vital Capacity [L]

  single visit

• Maximum Vital Capacity [L]

  single visit

Study Arms (2)

Type 1 diabetes group

Male participants with confirmed T1DM diagnosis for ≥1 year who have completed a marathon.

Control Group

Healthy male marathon runners matched by age, sex, and training background

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult marathon runners aged ≥18 years. Participants in the T1DM group with a confirmed diagnosis of T1DM for at least one year. The control group comprises healthy people with similar physical activity levels but no chronic health conditions.

You may qualify if:

• A diagnosis of T1DM for at least 1 year.
• Age ≥ 18 years.
• Written informed consent and adherence to the study protocol.

You may not qualify if:

• Pregnancy.
• Use of medications significantly affecting metabolism or exercise performance
• Presence of chronic medical or psychiatric conditions limiting safe participation
• Presence of advanced chronic complications of diabetes: proliferative retinopathy, diabetic kidney disease in stages III-V, cardiovascular diseases
• Inability to safely complete maximal exercise testing.

Sponsors & Collaborators

• Poznan University of Medical Sciences: lead

Study Sites (1)

Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences

Poznan, Greater Poland Voivodeship, 60-834, Poland

Location

Related Publications (7)

• Shepherd JA, Ng BK, Sommer MJ, Heymsfield SB. Body composition by DXA. Bone. 2017 Nov;104:101-105. doi: 10.1016/j.bone.2017.06.010. Epub 2017 Jun 16.

  PMID: 28625918 BACKGROUND

• Achamrah N, Delsoglio M, De Waele E, Berger MM, Pichard C. Indirect calorimetry: The 6 main issues. Clin Nutr. 2021 Jan;40(1):4-14. doi: 10.1016/j.clnu.2020.06.024. Epub 2020 Jul 2.

  PMID: 32709554 BACKGROUND

• Poole DC, Wilkerson DP, Jones AM. Validity of criteria for establishing maximal O2 uptake during ramp exercise tests. Eur J Appl Physiol. 2008 Mar;102(4):403-10. doi: 10.1007/s00421-007-0596-3. Epub 2007 Oct 30.

  PMID: 17968581 BACKGROUND

• Thuillier P, Domun N, Sonnet E, Le Ven F, Roudaut C, Kergus A, Kerlan V, Roudaut N. Prevention of exercise-induced hypoglycemia in 12 patients with type 1 diabetes running the Paris Marathon using continuous glucose monitoring: A prospective, single-center observational study. Diabetes Metab. 2022 Mar;48(2):101321. doi: 10.1016/j.diabet.2022.101321. Epub 2022 Jan 12.

  PMID: 35032674 BACKGROUND

• Grimm JJ, Muchnick S. Type I diabetes and marathon running. Diabetes Care. 1993 Dec;16(12):1624. doi: 10.2337/diacare.16.12.1624a. No abstract available.

  PMID: 8299461 BACKGROUND

• Riddell MC, Scott SN, Fournier PA, Colberg SR, Gallen IW, Moser O, Stettler C, Yardley JE, Zaharieva DP, Adolfsson P, Bracken RM. The competitive athlete with type 1 diabetes. Diabetologia. 2020 Aug;63(8):1475-1490. doi: 10.1007/s00125-020-05183-8. Epub 2020 Jun 12.

  PMID: 32533229 BACKGROUND

• Chimen M, Kennedy A, Nirantharakumar K, Pang TT, Andrews R, Narendran P. What are the health benefits of physical activity in type 1 diabetes mellitus? A literature review. Diabetologia. 2012 Mar;55(3):542-51. doi: 10.1007/s00125-011-2403-2. Epub 2011 Dec 22.

  PMID: 22189486 BACKGROUND

Related Links

• Poznan University of Medical Sciences in Poznań is conducting the project "Development of the University Centre for Sports and Medical Studies in Poznań" (No. NdS/544750/2021/2022), funded by the Ministry of Education and Science under th

MeSH Terms

Conditions

Diabetes Mellitus, Type 1; Motor Activity

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Autoimmune Diseases; Immune System Diseases; Behavior

Study Officials

• Dorota Zozulinska-Ziolkiewicz, MD, PhD

  Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of the Department of Internal Medicine and Diabetology

Study Record Dates

• First Submitted: April 13, 2025
• First Posted: April 20, 2025
• Study Start: August 30, 2023
• Primary Completion: October 22, 2023
• Study Completion: October 22, 2023
• Last Updated: April 20, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

PL (1)