The Investigation of Predicting Mortality and Morbidity in Patients Admitted to Intensive Care Unit With Thoracic Trauma Using Selected Biomarkers and Parameters

NCT06930222 | Completed

• 1 other identifier: SENCER-CELIK-001
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective study aimed to predict morbidity and mortality after thoracic trauma in intensive care unit evaluated clinical and biochemical data of 50 intensive care unit patients. The research examined demographic factors such as gender, age, and smoking status, trauma scoring systems like ISS and RTS as well as biomarkers such as Surfactant-d and oxygenation parameters including the ROX index, PaO₂/FiO₂ ratio and FiO₂.

Conditions

Thorax Traumas

Keywords

thorax trauma; ROX index; Surfactant-d

Outcome Measures

Primary Outcomes (2)

• Mortality Prediction Using ROX Index in Thoracic Trauma Patients

  To evaluate the predictive ability of the ROX index (unit: cmH₂O/L/s) for mortality in thoracic trauma patients. ROX index values were recorded at 1st, 3rd, and 7th days of hospitalization using standard clinical monitoring and ventilatory support parameters. Trends were analyzed in relation to survival outcomes.

  Measurements taken on day 1, day 3, and day 7 of hospitalization, following ICU admission.

• Mortality Prediction Using SP-D Levels in Thoracic Trauma Patients

  To assess the prognostic value of Surfactant Protein D (SP-D) levels (unit: ng/mL) for mortality prediction in thoracic trauma patients. SP-D levels were measured using an ELISA assay (Elabscience® Human Pulmonary Surfactant-associated Protein-D ELISA Kit) at 1st, 3rd, and 7th days to evaluate trends and correlations with survival outcomes.

  Measurements taken on day 1, day 3, and day 7 of hospitalization, following ICU admission.

Secondary Outcomes (6)

• Predictive Value of APACHE II Score in Mortality

  Measurements taken on day 1, day 3, and day 7 of hospitalization.

• Predictive Value of SOFA Score in Mortality

  Measurements taken on day 1, day 3, and day 7 of hospitalization.

• Predictive Value of TRISS Score in Mortality

  Measurements taken on day 1, day 3, and day 7 of hospitalization.

• Predictive Value of RTS Score in Mortality

  Measurements taken on day 1, day 3, and day 7 of hospitalization.

• CRP Levels and Mortality Prediction

  Measurements taken on day 1, day 3, and day 7 of hospitalization.

Other Outcomes (2)

• NEU/LYM Ratio and Mortality Correlation

  Measurements taken on day 1, day 3, and day 7 of hospitalization.

• Glasgow Coma Scale (GCS) and Mortality Correlation

  Measurements taken on day 1, day 3, and day 7 of hospitalization.

Study Arms (1)

thorax trauma patients

thorax trauma patients admitted to icu

Diagnostic Test: blood sampling

Interventions

blood sampling DIAGNOSTIC_TEST

blood samples obtained for 3 different days, limited to 5cc

thorax trauma patients

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with thoracic trauma admitted to icu

You may qualify if:

• Patients with thoracic trauma between the ages of 18-85
• Patients who have been monitored in intensive care for at least 1 week

You may not qualify if:

• Being outside the age range of 18-85
• Pregnant patients
• Patients whose intensive care follow-up lasted less than 1 week
• Patients who do not want to be included in the study
• Patients with a lung malignancy diagnosis before admission

Sponsors & Collaborators

• Suleyman Demirel University: lead

Study Sites (1)

Suleyman Demirel University

Isparta, 32260, Turkey (Türkiye)

Location

Related Publications (3)

• Determann RM, Royakkers AA, Haitsma JJ, Zhang H, Slutsky AS, Ranieri VM, Schultz MJ. Plasma levels of surfactant protein D and KL-6 for evaluation of lung injury in critically ill mechanically ventilated patients. BMC Pulm Med. 2010 Feb 16;10:6. doi: 10.1186/1471-2466-10-6.

  PMID: 20158912 BACKGROUND

• Baker JE, Millar DA, Heh V, Goodman MD, Pritts TA, Janowak CF. Does chest wall Organ Injury Scale (OIS) or Abbreviated Injury Scale (AIS) predict outcomes? An analysis of 16,000 consecutive rib fractures. Surgery. 2020 Jul;168(1):198-204. doi: 10.1016/j.surg.2020.04.032. Epub 2020 May 13.

  PMID: 32507628 BACKGROUND

• Lundin A, Akram SK, Berg L, Goransson KE, Enocson A. Thoracic injuries in trauma patients: epidemiology and its influence on mortality. Scand J Trauma Resusc Emerg Med. 2022 Dec 12;30(1):69. doi: 10.1186/s13049-022-01058-6.

  PMID: 36503613 BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

Hemogram Biochemical markers arterial blood gas analyses

MeSH Terms

Interventions

Blood Specimen Collection

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Officials

• pınar karabacak

  Suleyman Demirel University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 6 Weeks
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: RESEARCH ASSISTANT

Study Record Dates

• First Submitted: January 3, 2025
• First Posted: April 16, 2025
• Study Start: April 15, 2023
• Primary Completion: March 15, 2024
• Study Completion: April 15, 2024
• Last Updated: April 16, 2025

Record last verified: 2025-03

Locations

TU (1)