Prognostic Interest of Vasorin in Septic Shock

NCT06072508 | Completed

• 1 other identifier: PI2023_843_0073
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

In septic shock, the intensity and duration of low blood pressure can lead to a critical reduction in renal tissue perfusion and lead to the onset of more or less severe Acute Kidney Injury (AKI). Vasorin (Vasn) is a protein strongly expressed in large vessels and kidneys, whose functions are still poorly known. Previous experimental studies show that Vasn is associated with decreased Angiotensin II concentrations, a vessel contractility defect and early mortality. The investigators hypothesize that Vasn (the potential direct regulator of blood pressure) would be an early biomarker predicting the severity of AKI post septic shock, which may be associated with mortality from septic shock or lead to longer-term Chronic Renal Failure (CKD).

Conditions

Sepsis; Acute Kidney Injury

Keywords

vasorin; Sepsis; angiotensin II; Acute Kidney Injury

Outcome Measures

Primary Outcomes (2)

• correlation between vasorin concentration at day 0 and mortality rate

  day 0

• correlation between vasorin concentration at day 3 and mortality rate

  day 3

Interventions

Blood sampling BIOLOGICAL

Blood sampling (at day 0 and day 3) for Vasn, Angiotensin 2 and clotting markers.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥18 years old.
• Hospitalized in intensive care or medical resuscitation units.
• With a septic shock state defined by 2 mmol/l lactate sepsis, requiring vasopressors to maintain mean blood pressure 65 mmHg (despite adequate vascular filling).
• Whether or not they have developed AKI.
• Patient/family information and collection of non opposition

You may not qualify if:

• Patients with chronic respiratory failure.
• Pregnant women.
• Patients in palliative care.
• Information for the patient/someone close and collection of his opposition

Sponsors & Collaborators

• Centre Hospitalier Abbeville: collaborator
• Centre Hospitalier Universitaire, Amiens: lead

Study Sites (1)

CHU Amiens-Picardie

Amiens, 80000, France

Location

MeSH Terms

Conditions

Sepsis; Acute Kidney Injury

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 3, 2023
• First Posted: October 10, 2023
• Study Start: July 3, 2023
• Primary Completion: March 29, 2025
• Study Completion: March 29, 2025
• Last Updated: March 27, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)