Preoperative Anemia in the Oncology Population and Associated Mortality

NCT06928558 | Not Yet Recruiting

• 1 other identifier: Instituto Nacional del Cáncer
• Study Type: observational
• Target: 850
• Locations: 0 countries
• Sites: N/A

Brief Summary

Anemia is a highly prevalent condition in the surgical population (1, 2). On the other hand, the oncology population is at higher risk of developing anemia due to specific treatments for the disease, such as chemotherapy and radiotherapy. Preoperative anemia has been associated with an increased risk of postoperative morbidity and even mortality (3). Despite this, the prevalence of preoperative anemia in the Chilean oncology population has not been quantified. To answer this question, a retrospective cohort study was designed between January and December 2022 to quantify the prevalence of anemia in the surgical population of the National Cancer Institute. In addition, the impact on morbidity and mortality at 30 days, 6 months, and 1 year will be evaluated. Statistical analysis will be performed using R. Studio Version 2023.09.1+494 (2023.09.1+494).

Conditions

Anemia; Oncologic Surgery

Keywords

Anemia; Oncologic Surgery; Anesthesia

Outcome Measures

Primary Outcomes (1)

• Prevalence of preoperative anemia

  To quantify the prevalence of preoperative anemia in the oncology surgical population of the National Cancer Institute and its impact on postoperative outcomes.

  1 year

Study Arms (1)

Surgical oncology patients

Oncology patients over 18 years of age, scheduled for surgery with curative intent

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Consecutive patients operated at the National Cancer Institute will be included in a retrospective cohort study between January and December 2022.

You may qualify if:

• Patients over 18 years of age
• Oncologic surgery with curative intent

You may not qualify if:

• Emergency surgery
• Patients who received a preoperative transfusion
• Patients without a preoperative blood count

Sponsors & Collaborators

• University of Chile: lead

Related Publications (3)

• Sim YE, Abdullah HR. Implications of Anemia in the Elderly Undergoing Surgery. Clin Geriatr Med. 2019 Aug;35(3):391-405. doi: 10.1016/j.cger.2019.04.001. Epub 2019 May 27.

  PMID: 31230739 BACKGROUND

• Goodnough LT, Shander A, Spivak JL, Waters JH, Friedman AJ, Carson JL, Keating EM, Maddox T, Spence R. Detection, evaluation, and management of anemia in the elective surgical patient. Anesth Analg. 2005 Dec;101(6):1858-1861. doi: 10.1213/01.ANE.0000184124.29397.EB.

  PMID: 16301274 BACKGROUND

• Musallam KM, Tamim HM, Richards T, Spahn DR, Rosendaal FR, Habbal A, Khreiss M, Dahdaleh FS, Khavandi K, Sfeir PM, Soweid A, Hoballah JJ, Taher AT, Jamali FR. Preoperative anaemia and postoperative outcomes in non-cardiac surgery: a retrospective cohort study. Lancet. 2011 Oct 15;378(9800):1396-407. doi: 10.1016/S0140-6736(11)61381-0. Epub 2011 Oct 5.

  PMID: 21982521 BACKGROUND

MeSH Terms

Conditions

Anemia

Condition Hierarchy (Ancestors)

Hematologic Diseases; Hemic and Lymphatic Diseases

Central Study Contacts

Roberto A González, MD

CONTACT

+56999397515; robgonzalez@uchile.cl

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Anesthesiologist

Study Record Dates

• First Submitted: April 7, 2025
• First Posted: April 15, 2025
• Study Start: April 15, 2025
• Primary Completion: May 15, 2025
• Study Completion: June 15, 2025
• Last Updated: April 15, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share