Causes of Anemia Among Women of Reproductive Age

NCT05669209 | Completed

• 1 other identifier: EPHI_IRB_410_2021_1
• Study Type: observational
• Target: 881
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to assess the causes of anemia in women of reproductive age. The main questions it aims to answer are:

• What are the causes of anemia among women of reproductive age?
• What is the contribution of iron deficiency to overall anemia?
• What is the prevalence of hemoglobinopathies among women of reproductive age with anemia? Participants will be asked to respond to the interview questions, and provide blood, urine, and stool samples.

Conditions

Anemia

Keywords

Etiology; Anemia; Hemoglobin; Women of reproductive age

Outcome Measures

Primary Outcomes (2)

• Anemia prevalence

  Anemia is diagnosed when the hemoglobin concentration test result is less than 12g/dl.

  Single blood sample collected for the cross-sectional baseline study throughout a month on average.

• Iron deficiency anemia

  Iron deficiency anemia is diagnosed when serum ferritin concentration is less than 15μg/L and hemoglobin concentration is less than 12g/dl.

  Single blood sample collected for the cross-sectional baseline study throughout a month on average

Secondary Outcomes (1)

• Socioeconomic Status (SES)

  From the cross-sectional baseline study conducted throughout a month on average

Eligibility Criteria

• Age: 18 Years - 49 Years
• Gender Eligibility Details: The participants are expected to have the same gender identity as their biological sex.
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Women of reproductive age who are living in Kebribeyah district are the target population for this study. All non-pregnant women in the age range of 18-49 years living in three selected kebeles within the Kebribeyah district will be the study population. Our sample will be selected by systematic random sampling from a list of eligible women in the sampling frame. When there are two eligible women in the same household, one woman will be selected randomly.

You may qualify if:

• age range 18-49 years
• Permanent resident in the selected kebele (have lived for at least six months) in the kebele (village).

You may not qualify if:

• Women below or above the age range 18-49 years
• All pregnant women
• Women who are severely ill and incapacitated.
• Non-permanent resident women in the kebele (village)

Sponsors & Collaborators

• Ethiopian Public Health Institute: lead
• Oklahoma State University: collaborator
• Addis Ababa University: collaborator

Study Sites (1)

Ethiopian Public Health Institute

Addis Ababa, 1242, Ethiopia

Location

Related Publications (11)

• Cintron-Garcia J, Guddati AK. Effect of immigration on mortality trends in sickle cell patients. Am J Blood Res. 2020 Oct 15;10(5):172-178. eCollection 2020.

  PMID: 33224561 BACKGROUND

• Daru J, Colman K, Stanworth SJ, De La Salle B, Wood EM, Pasricha SR. Serum ferritin as an indicator of iron status: what do we need to know? Am J Clin Nutr. 2017 Dec;106(Suppl 6):1634S-1639S. doi: 10.3945/ajcn.117.155960. Epub 2017 Oct 25.

  PMID: 29070560 BACKGROUND

• Gebreegziabher T, Stoecker BJ. Iron deficiency was not the major cause of anemia in rural women of reproductive age in Sidama zone, southern Ethiopia: A cross-sectional study. PLoS One. 2017 Sep 12;12(9):e0184742. doi: 10.1371/journal.pone.0184742. eCollection 2017.

  PMID: 28898272 BACKGROUND

• Kassebaum NJ, Jasrasaria R, Naghavi M, Wulf SK, Johns N, Lozano R, Regan M, Weatherall D, Chou DP, Eisele TP, Flaxman SR, Pullan RL, Brooker SJ, Murray CJ. A systematic analysis of global anemia burden from 1990 to 2010. Blood. 2014 Jan 30;123(5):615-24. doi: 10.1182/blood-2013-06-508325. Epub 2013 Dec 2.

  PMID: 24297872 BACKGROUND

• Kibret KT, Chojenta C, D'Arcy E, Loxton D. Spatial distribution and determinant factors of anaemia among women of reproductive age in Ethiopia: a multilevel and spatial analysis. BMJ Open. 2019 Apr 4;9(4):e027276. doi: 10.1136/bmjopen-2018-027276.

  PMID: 30948614 BACKGROUND

• Khambalia AZ, Aimone AM, Zlotkin SH. Burden of anemia among indigenous populations. Nutr Rev. 2011 Dec;69(12):693-719. doi: 10.1111/j.1753-4887.2011.00437.x.

  PMID: 22133195 BACKGROUND

• Kohne E. Hemoglobinopathies: clinical manifestations, diagnosis, and treatment. Dtsch Arztebl Int. 2011 Aug;108(31-32):532-40. doi: 10.3238/arztebl.2011.0532. Epub 2011 Aug 8.

  PMID: 21886666 BACKGROUND

• Liyew AM, Teshale AB. Individual and community level factors associated with anemia among lactating mothers in Ethiopia using data from Ethiopian demographic and health survey, 2016; a multilevel analysis. BMC Public Health. 2020 May 24;20(1):775. doi: 10.1186/s12889-020-08934-9.

  PMID: 32448212 BACKGROUND

• Lopez A, Cacoub P, Macdougall IC, Peyrin-Biroulet L. Iron deficiency anaemia. Lancet. 2016 Feb 27;387(10021):907-16. doi: 10.1016/S0140-6736(15)60865-0. Epub 2015 Aug 24.

  PMID: 26314490 BACKGROUND

• Petry N, Olofin I, Hurrell RF, Boy E, Wirth JP, Moursi M, Donahue Angel M, Rohner F. The Proportion of Anemia Associated with Iron Deficiency in Low, Medium, and High Human Development Index Countries: A Systematic Analysis of National Surveys. Nutrients. 2016 Nov 2;8(11):693. doi: 10.3390/nu8110693.

  PMID: 27827838 BACKGROUND

• Teshale AB, Tesema GA, Worku MG, Yeshaw Y, Tessema ZT. Anemia and its associated factors among women of reproductive age in eastern Africa: A multilevel mixed-effects generalized linear model. PLoS One. 2020 Sep 11;15(9):e0238957. doi: 10.1371/journal.pone.0238957. eCollection 2020.

  PMID: 32915880 BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

We will collect blood, urine, and stool samples from all study participants. We will analyze for genetic causes of anemia (hemoglobinopathies) from the blood samples collected.

MeSH Terms

Conditions

Anemia

Condition Hierarchy (Ancestors)

Hematologic Diseases; Hemic and Lymphatic Diseases

Study Officials

• Masresha Tessema, PhD

  Ethiopian Public Health Institute (EPHI)

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Researcher for nutrition

Study Record Dates

• First Submitted: December 4, 2022
• First Posted: December 30, 2022
• Study Start: December 16, 2022
• Primary Completion: February 3, 2023
• Study Completion: February 3, 2023
• Last Updated: September 7, 2023

Record last verified: 2023-09

Locations

ET (1)