Influence of Standardized Perioperative Anesthetic, Analgesic Care on Outcome of Patients Undergoing Hip Fracture Surgeries

NCT06925789 | Withdrawn Phase 1 FDA Drug

• 1 other identifier: 25751
• Study Type: interventional
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this voluntary research study is to clarify whether or not a single injection nerve block done before surgery and after surgery nerve block catheter can effectively enhance recovery in elderly hip fracture patients in terms of reduced delirium, reduced length of stay and improved surgical and anesthesia outcomes. Delirium is a serious change in mental abilities. It results in confused thinking and a lack of awareness of someone's surroundings. The disorder usually comes on fast - within hours or a few days. Prolonged hospital stay is one of the risk factors for onset of delirium.

Conditions

Fractures, Hip; Local Anesthesia; Geriatric; Nerve Block

Keywords

Hip Fracture; Nerve blocks; Geriatric; Local anesthesia; Post operative outcomes

Outcome Measures

Primary Outcomes (2)

• Pain Control

  Pain control is determined by the Likert pain scale, where 0 is no pain and 10 as severe pain

  up to 48 hours post hospital admission.

• Opioid Use

  Identification of opioid use via the EMR, Opioids usage is measured at as number of morphine equivalents during the hospital admission.

  up to 48 hours post hospital admission.

Secondary Outcomes (1)

• Delirium score

  up to 48 hours post hospital admission.

Study Arms (1)

Local anesthesia to treat hip fracture in geriatric patients

EXPERIMENTAL

Drug: Ropivacaine

Interventions

Ropivacaine DRUG

The nerve block is performed when the patients are admitted to the hospital with diagnosed hip fractures. And another nerve block with catheter is performed for post-operative pain control in geriatric population with 0.25% Ropivacaine 30mls.

Local anesthesia to treat hip fracture in geriatric patients

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• Undergoing anesthesia for hip fracture surgery.
• Patients with fracture neck of femur fractures.
• Geriatric patients. (65 years and older)

You may not qualify if:

• Non-fracture hip patients
• non-geriatric patients. (Below 65 years old)
• Patients not able to consent themselves
• Non- English-speaking patients

Sponsors & Collaborators

• Milton S. Hershey Medical Center: lead

MeSH Terms

Conditions

Hip Fractures

Interventions

Ropivacaine

Condition Hierarchy (Ancestors)

Femoral Fractures; Fractures, Bone; Wounds and Injuries; Hip Injuries; Leg Injuries

Intervention Hierarchy (Ancestors)

Anilides; Amides; Organic Chemicals; Aniline Compounds; Amines

Study Officials

• Shubha Srinivasareddy, MD

  Penn State Health

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor of Anesthesia and Peri-operative care

Study Record Dates

• First Submitted: April 7, 2025
• First Posted: April 13, 2025
• Study Start: July 1, 2025
• Primary Completion: May 1, 2026
• Study Completion: May 1, 2026
• Last Updated: September 23, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share