Estrogen Levels and Postoperative Recovery in IVF Patients

NCT06925633 | Completed

• 1 other identifier: 2.11.2024-33440
• Study Type: observational
• Target: 98
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational study aims to evaluate the relationship between supraphysiologic serum estrogen levels and postoperative recovery quality in patients undergoing IVF procedures under general anesthesia. Estrogen is known to play a role in pain modulation and emotional responses, both of which influence postoperative recovery. The primary outcome is the quality of recovery score (QoR-15), and secondary outcomes include postoperative pain, nausea and vomiting, and discharge time. A total of 100 adult female patients will be included. The study seeks to provide better insight into how elevated estrogen levels may impact patient outcomes after anesthesia.

Conditions

In Vitro Fertilization; Postoperative Recovery; Estrogens; Anesthesia Recovery Period

Outcome Measures

Primary Outcomes (1)

• Postoperative Recovery Quality (QoR-15 Score)

  Assessed using the Quality of Recovery-15 (QoR-15) questionnaire at 24 and 72 hours postoperatively. The score ranges from 0 to 150, with higher scores indicating better recovery.

  24 hours and 72 hours after surgery

Secondary Outcomes (2)

• Postoperative Pain Intensity (NRS Score)

  24 and 72 hours after surgery

• Postoperative Nausea and Vomiting (VDS Score)

  24 and 72 hours after surgery

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: female
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of adult female patients aged 18 to 45 years undergoing transvaginal oocyte retrieval under general anesthesia as part of an IVF procedure. All participants will have ASA physical status I or II and be able to provide informed consent.

You may qualify if:

• Female patients aged between 18 and 45 years
• ASA physical status I or II
• Scheduled for transvaginal oocyte retrieval under general anesthesia as part of an IVF procedure
• Willing and able to provide written informed consent
• Able to understand and complete study questionnaires (QoR-15, HADS)

You may not qualify if:

• ASA physical status III or IV
• History of severe renal, hepatic, respiratory, or cardiovascular disease
• Current or chronic use of psychotropic medications
• Chronic use of opioids or benzodiazepines
• Known psychiatric or neurological disorders that may interfere with study participation
• Inability to provide informed consent or complete study questionnaires

Sponsors & Collaborators

• Konya City Hospital: lead

Study Sites (1)

Konya City Hospital

Konya, 42090, Turkey (Türkiye)

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor, Department of Anesthesiology and Reanimation

Study Record Dates

• First Submitted: April 7, 2025
• First Posted: April 13, 2025
• Study Start: April 20, 2025
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: January 6, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)