Multi-Modality Imaging Standard Cohort Of Cerebrovascular Disease

NCT06925178 | Recruiting DMC

• 1 other identifier: HX-B-2024061
• Study Type: observational
• Target: 800
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to establish a multi-center and multi-modality imaging standard cohort of cerebrovascular disease, analyze the potential mechanisms affecting the prognosis of cerebrovascular disease based on a variety of imaging methods, and explore potential therapeutic targets.

Conditions

Cerebrovascular Disease

Keywords

stroke; progonosis; imaging; cognitive disorder

Outcome Measures

Primary Outcomes (1)

• The incidence of unfavorable functional outcome

  Unfavorable functional outcome is defined as mRS Score 2-5. mRS is an efficient, reliable and simple scale to assess the recovery of neurological function and disability after stroke. The high score indicates the poor neurological recovery. The minimum score (0) means no symptoms at all. The maximum (6) means death.

  3 month after enrollment

Secondary Outcomes (6)

• The incidence of in-hospital complications

  duration of hospital stay（about 1 week）

• The incidence of unfavorable functional outcome

  6 and 12 months after enrollment

• The incidence of new vascular events

  3, 6 and 12 months after enrollment

• The incidence of recurrent stroke

  3, 6 and 12 months after enrollment

• The incidence of all-cause death

  3, 6 and 12 months after enrollment

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients aged 18-80 years old with acute cerebrovascular disease (hemorrhagic or ischemic stroke) within 7 days of onset； healthy adults.

You may qualify if:

• Age between 18 and 80 years old;
• Onset of symptoms within 7 days;
• Clinical diagnosis of cerebrovascular disease (ischemic stroke or hemorrhagic stroke) confirmed by head imaging (CT or MRI);
• Signed informed consent form.

You may not qualify if:

• Diagnosed with non-cerebrovascular diseases (such as central nervous system infections, epilepsy, and metabolic encephalopathy);
• Patients with contraindications to multimodal CT or MRI, functional near-infrared imaging, or those who cannot cooperate to complete the relevant examinations;
• Patients with a life expectancy of less than 3 months or those who cannot complete the study follow-up due to other reasons.

Sponsors & Collaborators

• Beijing Tiantan Hospital: lead

Study Sites (1)

Beijing Tiantan Hospital

Beijing, Beijing Municipality, 100070, China

RECRUITING

MeSH Terms

Conditions

Cerebrovascular Disorders; Stroke; Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Central Study Contacts

zixiao Li, PhD

CONTACT

00861067013383; lizixiao2008@hotmail.com

WENJIE WANG, PhD

CONTACT

18843113250; wangwenjie1129@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: November 20, 2024
• First Posted: April 13, 2025
• Study Start: January 1, 2025
• Primary Completion (Estimated): September 30, 2027
• Study Completion (Estimated): September 30, 2027
• Last Updated: April 13, 2025

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)