Thyroid Cancer in Surgical Treated Multinodular Goiter

NCT06924242 | Completed DMC

• 1 other identifier: 10
• Study Type: observational
• Target: 223
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate, based on existing knowledge, the incidence of occult thyroid carcinoma in a cohort of patients with MNG, providing new insights into the prevalence and characteristics of thyroid malignancies in MNG. It seeks to contribute to optimizing diagnostic evaluations for patients with multinodular goiter.

Conditions

Goiter, Nodular; Total Thyroidectomy; Thyroid Cancer

Outcome Measures

Primary Outcomes (1)

• incidence of occult thyroid carcinoma

  Incidence of occult thyroid carcinoma in a cohort of patients with multinodular goiter, providing new insights into the prevalence and characteristics of thyroid malignancies.

  6 years

Study Arms (1)

Patient with multinodular goiter who underwent total or partial thyroidectomy

Procedure: total or partial thyroidectomy

Interventions

total or partial thyroidectomy PROCEDURE

Total thyroidectomy is a surgical procedure that involves the complete removal of the thyroid gland. It is performed to treat conditions such as thyroid cancer, large goiters, or severe hyperthyroidism. The surgery is typically conducted under general anesthesia through an incision in the lower neck. Postoperative management may include hormone replacement therapy with levothyroxine to compensate for the loss of thyroid function. Potential complications include hypocalcemia due to parathyroid gland injury and vocal cord dysfunction from recurrent laryngeal nerve damage.

Patient with multinodular goiter who underwent total or partial thyroidectomy

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients of both sex with cancer incidence in multinodular thyroid goiter who underwent surgery in the same center

You may qualify if:

• patients diagnosed with multinodular goiter via thyroid ultrasound, with or without FNA cytology.
• patients who underwent surgery.
• availability of complete clinical data

You may not qualify if:

• history of thyroid carcinoma or other thyroid neoplasms.
• not completed postoperative follow up.
• patients with preoperative FNA results indicating malignancy (TIR 4-5), suspicion of malignancy (TIR 3), or indeterminate significance (TIR 1)

Sponsors & Collaborators

• University of Foggia: lead

Study Sites (1)

University of Foggia

Foggia, FG, 71122, Italy

Location

MeSH Terms

Conditions

Goiter, Nodular; Thyroid Neoplasms

Condition Hierarchy (Ancestors)

Goiter; Thyroid Diseases; Endocrine System Diseases; Endocrine Gland Neoplasms; Neoplasms by Site; Neoplasms; Head and Neck Neoplasms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Doctor

Study Record Dates

• First Submitted: March 28, 2025
• First Posted: April 11, 2025
• Study Start: January 1, 2018
• Primary Completion: May 30, 2024
• Study Completion: July 31, 2024
• Last Updated: April 11, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

IT (1)