7.0T Magnetic Resonance Imaging Study for Hepatic Encephalopathy

NCT06923254 | Not Yet Recruiting

• 1 other identifier: Hepatic encephalopathy-301
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

This clinical trial study aims to detect the imaging characteristics of patients with hepatic encephalopathy (HE) using 7-Tesla (7T) magnetic resonance imaging (MRI).

Conditions

Hepatic Encephalopathy (HE); MRI; fMRI Research

Keywords

Hepatic Encephalopathy; fMRI

Outcome Measures

Primary Outcomes (1)

• Functional connectivity and structural alterations between individuals with different subtypes of HE and healthy subjects.

  Functional connectivity calculation is mainly based on the BOLD sequence, which is used to describe the degree of connectivity between different brain regions and reflect the functional activity of the brain. Gray matter (GM) morphological destruction, cortical thickness, and subcortical nuclear volume in patients with hepatic encephalopathy were analyzed based on structural magnetic resonance imaging（sMRI）.

  5 years

Secondary Outcomes (1)

• Correlation between spectral features of clinical variables and spectral features of imaging.

  5 years

Study Arms (1)

7.0T Research

With the advantages of 7.0TMRI, we detect the imaging characteristics of patients with hepatic encephalopathy (HE).

Other: 7.0T MRI-Scan

Interventions

7.0T MRI-Scan OTHER

7.0T MRI-Scan

7.0T Research

Eligibility Criteria

• Age: 18 Years - 89 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with hepatic encephalopathy

You may qualify if:

• Patients with clinical suspected or diagnosed hepatic encephalopathy according to relevant guidelines.The patient's education level is above primary school level.
• Regular follow-up.

You may not qualify if:

• Contraindications to MRI.
• Patients with cerebrovascular disease, brain tumors, epilepsy, other neurodegenerative disease.

Sponsors & Collaborators

• Chinese PLA General Hospital: lead

Study Sites (1)

Chinese PLA General Hospital

Beijing, Beijing Municipality, 100853, China

Location

MeSH Terms

Conditions

Hepatic Encephalopathy

Condition Hierarchy (Ancestors)

Liver Failure; Hepatic Insufficiency; Liver Diseases; Digestive System Diseases; Brain Diseases, Metabolic; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Xin Lou

  Chinese PLA General Hospital

  STUDY CHAIR

Central Study Contacts

Jing Tang

CONTACT

+8618001184224; jessietang301@163.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Deputy Director of Department of Radiology

Study Record Dates

• First Submitted: April 4, 2025
• First Posted: April 11, 2025
• Study Start: April 3, 2025
• Primary Completion (Estimated): December 24, 2029
• Study Completion (Estimated): December 24, 2030
• Last Updated: April 11, 2025

Record last verified: 2025-04

Locations

CN (1)