iTBS/fMRI Study of Apex Control
2 other identifiers
interventional
40
1 country
2
Brief Summary
The objective of this study is to examine the effect of transcranial magnetic stimulation (TMS) on the prefrontal cortex and posterior parietal cortex.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Jan 2025
Typical duration for not_applicable
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 6, 2025
CompletedFirst Submitted
Initial submission to the registry
April 2, 2025
CompletedFirst Posted
Study publicly available on registry
April 9, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 30, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
November 30, 2026
February 2, 2026
April 1, 2025
1.9 years
April 2, 2025
January 30, 2026
Conditions
Outcome Measures
Primary Outcomes (2)
Change in PFC-PPC activation
blood oxygenation level dependent (BOLD) signal in areas of the prefrontal and posterior parietal cortex assessed with functional magnetic resonance imaging (fMRI) \[note, this measure has no units\]
baseline, pre-intervention and immediately after intervention
Change in PFC-PPC effective connectivity
effective connectivity among areas of the prefrontal and posterior parietal cortex in the blood oxygenation level dependent (BOLD) signal assessed with functional magnetic resonance imaging (fMRI) \[note, this measure has no units\]
baseline, pre-intervention and immediately after intervention
Secondary Outcomes (4)
Change in contextual control speed
baseline, pre-intervention and immediately after intervention
Change in contextual control accuracy
baseline, pre-intervention and immediately after intervention
Change in temporal control speed
baseline, pre-intervention and immediately after intervention
Change in temporal control accuracy
baseline, pre-intervention and immediately after intervention
Study Arms (3)
MFG-TMS
EXPERIMENTALTranscranial magnetic stimulation to the middle frontal gyrus. 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of resting motor threshold.
IPL-TMS
EXPERIMENTALTranscranial magnetic stimulation to the inferior parietal lobule. 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of resting motor threshold.
S1-TMS
ACTIVE COMPARATORTranscranial magnetic stimulation to the primary somatosensory cortex. 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of resting motor threshold.
Interventions
Transcranial magnetic stimulation delivered to the scalp targeting specific brain structures via stereotactic guidance.
Eligibility Criteria
You may qualify if:
- Between the ages of 18 and 30
- Right-handed
- Native English speaker or fluent by the age of 6
You may not qualify if:
- History of psychiatric disorders
- History of neurological disorders
- Receiving medications for psychiatric or neurological disorders
- Familial history of epilepsy
- Taking any drugs or medications that are pro-epileptic
- Tinnitus
- Women who are pregnant
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Florida State University Psychology Department Building
Tallahassee, Florida, 32306, United States
FSU MRI Facility
Tallahassee, Florida, 32306, United States
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Derek Nee, PhD
Florida State University
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
April 2, 2025
First Posted
April 9, 2025
Study Start
January 6, 2025
Primary Completion (Estimated)
November 30, 2026
Study Completion (Estimated)
November 30, 2026
Last Updated
February 2, 2026
Record last verified: 2025-04
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- ANALYTIC CODE
- Time Frame
- Within a year following publication of findings
- Access Criteria
- Behavioral and imaging data will be accessible from NIMH Data Archive
Behavioral and imaging data will be shared