iTBS/fMRI Study of Hierarchical Control in the PFC
2 other identifiers
interventional
54
1 country
2
Brief Summary
The objective of this study is to examine the effect of transcranial magnetic stimulation (TMS) on the prefrontal cortex and posterior parietal cortex.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started May 2023
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 15, 2023
CompletedFirst Submitted
Initial submission to the registry
May 18, 2023
CompletedFirst Posted
Study publicly available on registry
May 26, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 2, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
December 2, 2024
CompletedResults Posted
Study results publicly available
February 25, 2026
CompletedFebruary 25, 2026
February 1, 2026
1.6 years
May 18, 2023
February 4, 2026
February 4, 2026
Conditions
Outcome Measures
Primary Outcomes (2)
PFC-PPC Effective Connectivity
effective connectivity among areas of the prefrontal and posterior parietal cortex in the blood oxygenation level dependent (BOLD) signal assessed with functional magnetic resonance imaging (fMRI) \[note, this measure has no units, but effective connectivity is a rate measure, so is expressed in Hertz\]
baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS)
PFC-PPC Activation
blood oxygenation level dependent (BOLD) signal in areas of the prefrontal and posterior parietal cortex assessed with functional magnetic resonance imaging (fMRI) \[note, this measure has no units\]
baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS)
Secondary Outcomes (6)
Temporal Control Performance (Error Rate)
baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS)
Contextual Control Performance (Error Rate)
baseline, pre-intervention and immediately after intervention (t minutes to 1 hour post-TMS)
Temporal x Contextual Control Performance (Error Rate)
baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS)
Temporal Control Performance (Reaction Time)
baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS)
Contextual Control Performance (Reaction Time)
baseline, pre-intervention and immediately after intervention (5 minutes to 1 hour post-TMS)
- +1 more secondary outcomes
Study Arms (3)
FPl-TMS
EXPERIMENTALTranscranial magnetic stimulation to the lateral frontal pole. 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold.
MFG-TMS
EXPERIMENTALTranscranial magnetic stimulation to the middle frontal gyrus. 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold.
S1-TMS
ACTIVE COMPARATORTranscranial magnetic stimulation to the primary somatosensory cortex. 600 pulses delivered in 50 Hz bursts every 5 Hz for 2 seconds repeated every 10 seconds at 80% of active motor threshold.
Interventions
Transcranial magnetic stimulation delivered to the scalp targeting specific brain structures via stereotactic guidance.
Eligibility Criteria
You may qualify if:
- Between the ages of 18 and 30
- Right-handed
- Native English speaker or fluent by the age of 6
You may not qualify if:
- History of psychiatric disorders
- History of neurological disorders
- Receiving medications for psychiatric or neurological disorders
- Familial history of epilepsy
- Taking any drugs or medications that are pro-epileptic
- Metal anywhere in the head excluding the mouth
- Tinnitus
- Women who are pregnant
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Florida State University Psychology Department Building
Tallahassee, Florida, 32303, United States
FSU MRI Facility
Tallahassee, Florida, 32306, United States
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Derek Nee
- Organization
- Florida State University
Study Officials
- PRINCIPAL INVESTIGATOR
Derek E Nee, PhD
Florida State University
Publication Agreements
- PI is Sponsor Employee
- Yes
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
May 18, 2023
First Posted
May 26, 2023
Study Start
May 15, 2023
Primary Completion
December 2, 2024
Study Completion
December 2, 2024
Last Updated
February 25, 2026
Results First Posted
February 25, 2026
Record last verified: 2026-02
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- ANALYTIC CODE
- Time Frame
- Within a year following publication of findings
- Access Criteria
- Behavioral and imaging data will be accessible from NIMH Data Archive
Behavioral and imaging data will be shared