Effect of CGF on Postoperative Pain After Third Molar Surgery

NCT06918327 | Completed

• 1 other identifier: EGE-DHF-MZ-002
• Study Type: interventional
• Target: 49
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to evaluate the effects of concentrated growth factor (CGF) on pain after bilateral impacted third molar surgery and to determine its contribution to the healing process. The main question it aims to answer is: Is CGF effective on reducing the pain in impacted third molar surgery? Researchers compare the pain on the CGF-applied and CGF free sides after impacted third molar surgery. Postoperative pain is assessed using the Visual Analogue Scale. TThe postoperative outcomes including pain are clinically assessed at different-time intervals (1-7 days).

Conditions

Oral Complication

Keywords

Pain; Third molar; VAS scale

Outcome Measures

Primary Outcomes (1)

• Postoperative pain on CGF-applied and CGF free sides in bilateral impacted third molar surgery

  The primary outcome measure is postoperative pain on CGF-applied and CGF free sides in bilateral impacted third molar surgery. Postoperative pain is assessed using the Visual Analogue Scale (VAS). Patients are asked to mark the pain they felt on the scale (10 cm long line) on the (1-7) days after the operation. The end of the line indicates unbearable pain, the beginning indicates no pain.

  The postoperative outcomes including pain are clinically assessed at different-time intervals (1st, 2nd, 3rd, 4th, 5th, 6th and 7th days).

Study Arms (2)

CGF

EXPERIMENTAL

Participants received CGF after the operation on one side

Other: Concentrated Growth Factor; Other: non-CGF

non-CGF

NO INTERVENTION

The other extraction socket is left empty

Interventions

Concentrated Growth Factor OTHER

Bilaterally impacted third molar of the patients are removed surgically and concentrated growth factor is placed in one of the extraction sockets.

CGF

non-CGF OTHER

The other extraction socket is left empty for control purposes.

CGF

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Patients with bilateral, symmetrical, bone-retained (vertical, mesioangular, horizontal) impacted wisdom teeth in the mandible, regardless of gender
• Patients without any systemic disease
• Patients who have been informed about the duration, purpose and requirements of the study and who have signed the informed consent form voluntarily.

You may not qualify if:

• Having a disease affecting general health that requires the application of prophylactic antimicrobial agents
• Having a systemic viral, fungal or bacterial infection
• Patients with acute or chronic maxillary sinusitis
• Suspected or diagnosed pregnancy and nursing mothers
• Patients with heart and vascular diseases
• Patients with liver disease, haematological disease and neoplastic disease
• Patients who have recently received anti-inflammatory therapy
• Patients with chronic medication use (antihistamines, NSAIDs, steroids and antidepressants)
• Patients predisposed to psychotic or psychopathic tendencies
• Patients with rheumatic diseases, blood diseases, diabetes mellitus
• Patients at cardiological risk of infective endocarditis
• Patients under antibiotic pressure

Sponsors & Collaborators

• Ege University: lead

Study Sites (1)

Ege University Faculty of Dentistry

Izmir, Bornova, 35040, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pain

Condition Hierarchy (Ancestors)

Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Mert Zeytinoğlu

  Ege University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc. Prof. Dr.

Study Record Dates

• First Submitted: March 31, 2025
• First Posted: April 9, 2025
• Study Start: May 1, 2017
• Primary Completion: January 1, 2018
• Study Completion: June 5, 2018
• Last Updated: April 20, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)