Effect of CGF on Postoperative Edema in Third Molar Surgery

NCT06893523 | Completed

• 1 other identifier: EGE-DHF-MZ-001
• Study Type: interventional
• Target: 49
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to evaluate the effects of concentrated growth factor (CGF) on edema after bilateral impacted third molar surgery and to determine its contribution to the healing process. The main question it aims to answer is: Is CGF effective on reducing the edema in impacted third molar surgery? Researchers compare the edema amount on the CGF-applied and CGF free sides after impacted third molar surgery. The edema measurements are performed on the second and seventh days.

Conditions

Oral Complication

Keywords

Edema; Third molar

Outcome Measures

Primary Outcomes (1)

• Postoperative edema amounts on CGF-applied and CGF free sides in bilateral impacted third molar surgery

  Edema measurements are made at three points on the patients before the operation, on the 2nd and 7th days after the operation. These measurements are made between the external canthus-angulus mandible, tragus-commissura and tragus-pogonium. In order to ensure standardization, all measurements are made by the same physician with the patient's head position in the same direction.

  Before operation to the end of the operation at seven days

Study Arms (2)

CGF

EXPERIMENTAL

Participants received CGF after the operation on one side

Other: Concentrated Growth Factor; Other: Non-CGF

non-CGF

NO INTERVENTION

The other extraction socket is left empty

Interventions

Concentrated Growth Factor OTHER

Bilaterally impacted third molar of the patients areremoved surgically and concentrated growth factor isplaced in one of the extraction sockets.

CGF

Non-CGF OTHER

The other extraction socket is left empty for control purposes.

CGF

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Patients with bilateral, symmetrical, bone-retained (vertical, mesioangular, horizontal) impacted wisdom teeth in the mandible, regardless of gender
• Patients without any systemic disease
• Patients who have been informed about the duration, purpose and requirements of the study and who have signed the informed consent form voluntarily.-

You may not qualify if:

• Having a disease affecting general health that requires the application of prophylactic antimicrobial agents
• Having a systemic viral, fungal or bacterial infection
• Patients with acute or chronic maxillary sinusitis
• Suspected or diagnosed pregnancy and nursing mothers
• Patients with heart and vascular diseases
• Patients with liver disease, haematological disease and neoplastic disease
• Patients who have recently received anti-inflammatory therapy
• Patients with chronic medication use (antihistamines, NSAIDs, steroids and antidepressants)
• Patients predisposed to psychotic or psychopathic tendencies
• Patients with rheumatic diseases, blood diseases, diabetes mellitus
• Patients at cardiological risk of infective endocarditis
• Patients under antibiotic pressure

Sponsors & Collaborators

• Ege University: lead

Study Sites (1)

Ege University Faculty of Dentistry

Izmir, Bornova, 35040, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Edema

Condition Hierarchy (Ancestors)

Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Mert Zeytinoglu

  Ege University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc. Prof. Dr.

Study Record Dates

• First Submitted: March 12, 2025
• First Posted: March 25, 2025
• Study Start: May 1, 2017
• Primary Completion: January 1, 2018
• Study Completion: June 5, 2018
• Last Updated: March 25, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)