A Study Comparing Doxycycline and Levofloxacin for Treating COPD Exacerbations
DOLE-COPD
Comparison of Clinical Cure Rate of Doxycycline and Levofloxacin in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease
1 other identifier
interventional
188
1 country
1
Brief Summary
This study will include patients with chronic obstructive pulmonary disease (COPD) who present with an acute exacerbation. Participants will be randomly assigned to receive either doxycycline or levofloxacin for 5 days. The aim is to compare how effective each antibiotic is in improving symptoms after 2 days of treatment.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Apr 2025
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 19, 2025
CompletedFirst Posted
Study publicly available on registry
April 8, 2025
CompletedStudy Start
First participant enrolled
April 15, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 28, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
July 31, 2025
CompletedApril 8, 2025
March 1, 2025
3 months
March 19, 2025
April 4, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Clinical Cure Rate
1. A decrease in the respiratory rate by 20% from the baseline measurement. 2. Restoration of Oxygen saturation levels to within the range of 88-92% on room air. 3. CRP\<10ng/ml 4. decrease in sputum quantity 5. reduction in body temperature below 99•F 6. TLC \<11,000
7 days
Study Arms (2)
Arm 1
ACTIVE COMPARATORDoxycycline will be given to this group
Arm 2
ACTIVE COMPARATORLevofloxacin in copd patients
Interventions
Eligibility Criteria
You may qualify if:
- diagnosed cases of COPD Exacerbation of COPD Able to provide Written consent No anti biotic taken with in past 4 weeks
You may not qualify if:
- hypersensitivity to any drugs Pneumonia evidence on xray/ hrct chest Any other pulmonary condition e.g asthma Pregnancy/breast feeding Taking treatment for other active infections
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Amina Aslamlead
Study Sites (1)
General hospital
Lahore, Pakistan
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER GOV
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- AAslam
Study Record Dates
First Submitted
March 19, 2025
First Posted
April 8, 2025
Study Start
April 15, 2025
Primary Completion
July 28, 2025
Study Completion
July 31, 2025
Last Updated
April 8, 2025
Record last verified: 2025-03