Visual Perception in Schizophrenia

NCT06911931 | Recruiting

• 2 other identifiers: STUDY00007500R21MH140245
• Study Type: interventional
• Target: 84
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to identify novel markers of psychosis using electroencephalography (EEG).

Conditions

Schizophrenia Disorders; Bipolar Disorder; Schizo Affective Disorder

Outcome Measures

Primary Outcomes (1)

• mean amplitude of EEG visual response

  Day 1

Study Arms (1)

All participants

EXPERIMENTAL

Other: EEG measure of visual processing

Interventions

EEG measure of visual processing OTHER

Non-invasive scalp EEG measure of early cortical visual processing.

All participants

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• All Subjects
• Aged 18-65
• /32 visual acuity or better (using in-house optical correction, if necessary)
• An ability to speak English well enough to complete study assessments and to consent to the study
• Subjects with Schizophrenia-Spectrum Disorder
• Meets DSM-5 diagnostic criteria for schizophrenia, schizoaffective disorder, or schizophreniform disorder as confirmed by the Structured Interview for DSM-5 (SCID-5).
• Subjects with Bipolar Disorder
• Meets DSM-5 diagnostic criteria for bipolar disorder (type I, II, or unspecified) as confirmed by the Structured Interview for DSM-5 (SCID-5).

You may not qualify if:

• All subjects
• Presence of characteristics that could impair one's ability to comprehend the nature of the study, provide informed consent, or understand the assessment questions, including the following:
• Subject cannot read and understand the instructions well enough to complete the tasks or cannot provide informed consent.
• Intellectual impairment (WRAT-5 score \< 70) (at the discretion of experimenter);
• Actively intoxicated, as shown via patient self-report or staff report;
• Substance use disorder in the past 3 months;
• Subject considered high risk for suicidal acts (i.e., active suicidal ideation as determined by clinical interview OR any suicide attempt in 30 days prior to screening);
• Subject violence (involving severe/lethal means or violence occurring in prior 6 months) or extreme agitation.
• Being in a current manic state
• Head injury with loss of consciousness greater than 10 minutes (at the discretion of the experimenter).
• Subject has had electroconvulsive therapy (ECT) in the past 8 weeks;
• Diagnosed with a neurological condition (tumor, stroke, brain injury) or neurological disorder, including seizure disorders. Diagnosed with pervasive developmental disorder (phone screen or medical records)
• Lazy eye or squint or other known ocular pathology
• Healthy Control Subjects
• Any lifetime psychotic disorder or history of psychiatric hospitalization (self disclosure);

Sponsors & Collaborators

• University of Rochester: lead
• National Institute of Mental Health (NIMH): collaborator

Study Sites (1)

University of Rochester

Rochester, New York, 14642, United States

RECRUITING

MeSH Terms

Conditions

Schizophrenia; Bipolar Disorder; Psychotic Disorders

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders; Bipolar and Related Disorders; Mood Disorders

Central Study Contacts

Edmund Lalor, PhD

CONTACT

585-275-3077; Edmund_Lalor@URMC.Rochester.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: March 28, 2025
• First Posted: April 4, 2025
• Study Start: November 3, 2025
• Primary Completion (Estimated): January 31, 2027
• Study Completion (Estimated): January 31, 2027
• Last Updated: November 12, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will share

Locations

US (1)