Potential Cross-Talk Between Arterial Calcifications

NCT06895265 | Completed

• 1 other identifier: 18.2.2024/66
• Study Type: observational
• Target: 921
• Locations: 1 country
• Sites: 1

Brief Summary

Potential Cross-Talk Between Arterial Calcifications Background Vascular calcification is a key component of atherosclerosis. This study investigates the potential correlations between aortic and coronary calcifications detected via abdominal CT, considering age-related variations, to explore the possibility of cross-talk. Method A total of 921 patients (n=921) \[male: 508 (55%), female: 413 (44.7%)\] were divided into three age groups: 40-49, 50-69, and 70-90 years. Non-contrast abdominal CT scans were evaluated for calcifications in the coronary arteries, thoracic aorta, abdominal aorta (AA(1): suprarenal, AA(2): renal, AA(3): infrarenal), iliac arteries, and femoral artery. Aortic branches were categorized by calcification levels: none, \<25%, 25-50%, ≥50%

Conditions

Vascular Calcification; Atherosclerosis of Artery

Keywords

Vascular calcification

Outcome Measures

Primary Outcomes (1)

• Recording of coronary and abdominal aorta, as well as common, iliac, and femoral artery calcifications.

  1-coronary artery calcifications, (CAC)\] were visually classified in a simplified manner as either present or absent for a faster assessment 2-Following the examination of coronary lesions and the thoracic aorta for calcification, the abdominal aortic area was analyzed. Aortic calcifications were classified in horizontal cross-sectional slices.Regional vessel segments were evaluated based on the extent of calcification and categorized as: none, \<25%, 25-50%, and ≥50-100%.

  "Data were collected over a period of ten months."

Study Arms (1)

Patients with abdominal CT records

The study group consisted of non-contrast abdominal CT records from 921 patients, aged between 40 and 90 years.

Eligibility Criteria

• Age: 40 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients aged 40-90 with non-contrast abdominal CT records.

You may qualify if:

• Hypertension, Hyperlipidemia, Diabetes Mellitus, Coronary Artery Disease, Chronic Obstructive Pulmonary Disease

You may not qualify if:

• Chronic renal failure Hemodialysis patients

Sponsors & Collaborators

• Ankara Ataturk Sanatorium Training and Research Hospital: lead

Study Sites (1)

Ankara Atatürk Sanatoryum RTH

Ankara, Türki̇ye, 06570, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Vascular Calcification

Condition Hierarchy (Ancestors)

Calcinosis; Calcium Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: cardıologist

Study Record Dates

• First Submitted: February 26, 2025
• First Posted: March 26, 2025
• Study Start: February 2, 2024
• Primary Completion: December 30, 2024
• Study Completion: January 1, 2025
• Last Updated: March 26, 2025

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will share
• Shared Documents: SAP, CSR
• Time Frame: De-identified individual participant data (IPD) and supporting information will be available starting 6 months after publication of study results. Data will be accessible for a period of 5 years.
• Access Criteria: Researchers and qualified professionals will be able to access de-identified individual participant data (IPD) and supporting documents, including study protocols and statistical analysis plans. Data will be available through a secure online repository, requiring a formal data-sharing agreement and ethical approval

Locations

TU (1)