Periodontitis and Atherosclerotic-related Arterial Stenosis
The Relationship Between Periodontitis and Atherosclerotic-related Arterial Stenosis in the Chinese Population
1 other identifier
observational
1,000
0 countries
N/A
Brief Summary
This study aimed to evaluate the association between periodontitis and atherosclerosis of the cerebral vasculature in the Chinese population.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Apr 2020
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 8, 2020
CompletedFirst Posted
Study publicly available on registry
March 11, 2020
CompletedStudy Start
First participant enrolled
April 1, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2022
CompletedMarch 11, 2020
March 1, 2020
1.9 years
March 8, 2020
March 10, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
The relationship between atherosclerotic-related stenosis in different brain arteries and tooth loss categories
The arteries of the brains will be partitioned into the following segments: common carotid artery (CCA), internal carotid arteries (ICA, C1-C7), the external carotid artery (ECA), the anterior cerebral artery (ACA, A1-A2), the middle cerebral artery (MCA, M1-M2), the posterior cerebral artery (PCA), the basilar artery (BA), the vertebral artery (VA,V1-V4) and the subclavicular artery (SUB) .The chi-square test and Fisher's exact test will be used, as appropriate, to estimate the relationship between tooth loss and stenosis distributed in different branches
1 day
Secondary Outcomes (1)
The relationship between the severity of artery stenosis and tooth loss categories
1 day
Study Arms (4)
0-9 missing teeth
participants with 0-9 missing teeth
10-19 missing teeth
participants with 10-19 missing teeth
23-31 missing teeth
participants with 23-31 missing teeth
Edentulous
participants with no teeth
Eligibility Criteria
Study population are people who underwent cerebral angiography at Guangdong Provincial Hospital of Chinese Medicine from April 2020 to April 2022 and meat the inclusion and exclusion criteria
You may qualify if:
- subjects who underwent cerebral angiography at Guangdong Provincial Hospital of Chinese Medicine from April 2020 to December 2021
- subjects who voluntarily participated in this study and provided informed consent.
You may not qualify if:
- intracranial and extracranial artery stenosis caused by vascular inflammation, systemic connective tissue disease, and muscle fibre structure hypoplasia
- inability to cooperate with the investigation
- intracranial aneurysm and cerebral arteriovenous malformation confirmed by cerebral angiography
- receipt of periodontal treatment in the previous 24 months.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Biospecimen
All the blood samples will be stored in the biological resource centre of the our research centre after written informed consent obtained from all subjects who voluntarily participated in this clinical study.
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 8, 2020
First Posted
March 11, 2020
Study Start
April 1, 2020
Primary Completion
March 1, 2022
Study Completion
April 1, 2022
Last Updated
March 11, 2020
Record last verified: 2020-03